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GPR87

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GPR87

Identifiers

Aliases

GPR87, GPR95, KPG_002, FKSG78, G protein-coupled receptor 87

External IDs

OMIM:606379;MGI:1934133;HomoloGene:13021;GeneCards:GPR87;OMA:GPR87 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q25.1	Start	151,294,086bp^[1]
Band	3q25.1	End	151,316,820bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 D	Start	59,086,344bp^[2]
Band	3\|3 D	End	59,102,525bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

hair follicle

skin of arm

gingival epithelium

oral cavity

skin of thigh

skin of abdomen

cervix epithelium

vulva

amniotic fluid

epithelium of nasopharynx

Top expressed in

esophagus

hair follicle

skin of external ear

skin of back

cornea

skin of abdomen

conjunctival fornix

transitional epithelium of urinary bladder

condyle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled purinergic nucleotide receptor activity G protein-coupled receptor activity signal transducer activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase activity signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway biological process
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


53836


84111

Ensembl


ENSG00000138271


ENSMUSG00000051431

UniProt


Q9BY21


Q99MT7

RefSeq (mRNA)


NM_023915


NM_001302203 NM_032399

RefSeq (protein)


NP_076404


NP_001289132

Location (UCSC)

Chr 3: 151.29 – 151.32 Mb

Chr 3: 59.09 – 59.1 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 87 is aprotein that in humans is encoded by theGPR87gene.^[5]^[6]

G protein-coupled receptors play a role in cell communication. They are characterized by an extracellular N terminus, 7 transmembrane regions, and an intracellular C terminus.[supplied by OMIM]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000138271 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000051431 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wittenberger T, Schaller HC, Hellebrand S (Mar 2001). "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors".J Mol Biol.307 (3):799–813.doi:10.1006/jmbi.2001.4520.PMID 11273702.
^^a ^b"Entrez Gene: GPR87 G protein-coupled receptor 87".

Lee DK, Nguyen T, Lynch KR, et al. (2001). "Discovery and mapping of ten novel G protein-coupled receptor genes".Gene.275 (1):83–91.doi:10.1016/S0378-1119(01)00651-5.PMID 11574155.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–16903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–45.doi:10.1038/ng1285.PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–2127.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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