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GPR39

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GPR39

Identifiers

Aliases

GPR39, G protein-coupled receptor 39

External IDs

OMIM:602886;MGI:1918361;HomoloGene:20380;GeneCards:GPR39;OMA:GPR39 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q21.2	Start	132,416,805bp^[1]
Band	2q21.2	End	132,646,582bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 E3	Start	125,604,732bp^[2]
Band	1\|1 E3	End	125,801,599bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

secondary oocyte

gonad

sperm

ganglionic eminence

ventricular zone

right uterine tube

mucosa of transverse colon

internal globus pallidus

nucleus accumbens

Top expressed in

transitional epithelium of urinary bladder

yolk sac

spermatid

duodenum

stomach

seminal vesicula

jejunum

embryo

esophagus

epithelium of stomach

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity metal ion binding
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	G protein-coupled receptor signaling pathway signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2863


71111

Ensembl


ENSG00000183840


ENSMUSG00000026343

UniProt


O43194


Q5U431

RefSeq (mRNA)


NM_001508


NM_027677

RefSeq (protein)


NP_001499


NP_081953

Location (UCSC)

Chr 2: 132.42 – 132.65 Mb

Chr 1: 125.6 – 125.8 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

G-protein coupled receptor 39 is aprotein that in humans is encoded by theGPR39gene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000183840 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000026343 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH (Mar 1998). "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors".Genomics.46 (3):426–34.doi:10.1006/geno.1997.5069.PMID 9441746.
^"Entrez Gene: GPR39 G protein-coupled receptor 39".

Popovics P, Stewart AJ (2011)."GPR39: A Zn2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions".Cell. Mol. Life Sci.68 (1):85–95.doi:10.1007/s00018-010-0517-1.PMC 11114682.PMID 20812023.S2CID 20170402.
Bonaldo MF, Lennon G, Soares MB (1997)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6 (9):791–806.doi:10.1101/gr.6.9.791.PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Holst B, Holliday ND, Bach A, et al. (2005)."Common structural basis for constitutive activity of the ghrelin receptor family".J. Biol. Chem.279 (51):53806–17.doi:10.1074/jbc.M407676200.PMID 15383539.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005)."Generation and annotation of the DNA sequences of human chromosomes 2 and 4".Nature.434 (7034):724–31.Bibcode:2005Natur.434..724H.doi:10.1038/nature03466.PMID 15815621.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.
Holst B, Egerod KL, Schild E, et al. (2007)."GPR39 signaling is stimulated by zinc ions but not by obestatin".Endocrinology.148 (1):13–20.doi:10.1210/en.2006-0933.PMID 16959833.
Lauwers E, Landuyt B, Arckens L, et al. (2006). "Obestatin does not activate orphan G protein-coupled receptor GPR39".Biochem. Biophys. Res. Commun.351 (1):21–5.doi:10.1016/j.bbrc.2006.09.141.PMID 17054911.
Egerod KL, Holst B, Petersen PS, et al. (2007)."GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue".Mol. Endocrinol.21 (7):1685–98.doi:10.1210/me.2007-0055.PMID 17488974.
Yasuda S, Miyazaki T, Munechika K, et al. (2007). "Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum".J. Recept. Signal Transduct. Res.27 (4):235–46.doi:10.1080/10799890701506147.PMID 17885920.S2CID 33411716.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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