GPR37 has been shown tointeract withHSPA1A[9] andParkin (ligase).[9][10] GPR37 is a receptor forprosaposin. It was previously thought to be a receptor forhead activator, aneuropeptide found in thehydra, but early reports of head activator in mammals were never confirmed.[11] To address challenges in confirming ligand-GPR37 interactions usingrecombinant GPR37 expressed inHEK293 cells, recent research has turned toprimary cell cultures, leading to successful ligand identification.[12] These investigations have unveiled the involvement ofosteocalcin with GPR37 to regulate processes such as oligodendrocyte differentiation, myelination, myelin production, andremyelination following demyelinating injuries.[13] Furthermore, osteocalcin treatment has demonstrated protective effects againstLipopolysaccharide-induced inflammation, which are absent in GPR37-deficient mice.[14]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (October 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library".Genomics.45 (1):68–77.doi:10.1006/geno.1997.4900.PMID9339362.
Zeng Z, Su K, Kyaw H, Li Y (April 1997). "A novel endothelin receptor type-B-like gene enriched in the brain".Biochemical and Biophysical Research Communications.233 (2):559–567.doi:10.1006/bbrc.1997.6408.PMID9144577.
Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, et al. (December 2006). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin".Journal of Neurochemistry.99 (6):1456–1469.doi:10.1111/j.1471-4159.2006.04155.x.hdl:2115/17141.PMID17059562.S2CID6256027.
