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GPR22

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GPR22

Identifiers

Aliases

GPR22, G protein-coupled receptor 22

External IDs

OMIM:601910;MGI:1920260;HomoloGene:18420;GeneCards:GPR22;OMA:GPR22 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q22.3	Start	107,470,018bp^[1]
Band	7q22.3	End	107,475,684bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 A3	Start	31,756,866bp^[2]
Band	12\|12 A3	End	31,763,946bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

superior frontal gyrus

prefrontal cortex

testicle

dorsolateral prefrontal cortex

Brodmann area 9

anterior cingulate cortex

primary visual cortex

right frontal lobe

left ventricle

hippocampus proper

Top expressed in

subiculum

interventricular septum

subdivision of hippocampus

Region I of hippocampus proper

hippocampus proper

dentate gyrus

lobe of cerebellum

cerebellar vermis

primary motor cortex

piriform cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	peptide binding signal transducer activity G protein-coupled receptor activity
Cellular component	integral component of membrane plasma membrane membrane integral component of plasma membrane
Biological process	cellular response to hormone stimulus signal transduction response to peptide G protein-coupled receptor signaling pathway cell projection organization
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2845


73010

Ensembl


ENSG00000172209 ENSG00000283812


ENSMUSG00000044067

UniProt


Q99680 Q3KNS9


Q8BZL4

RefSeq (mRNA)


NM_005295


NM_175191

RefSeq (protein)


NP_005286 NP_005286.2


NP_780400

Location (UCSC)

Chr 7: 107.47 – 107.48 Mb

Chr 12: 31.76 – 31.76 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 22 is aprotein that in humans is encoded by theGPR22gene.^[5]^[6]

References

[edit]

^^a ^b ^cENSG00000283812 GRCh38: Ensembl release 89: ENSG00000172209, ENSG00000283812 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000044067 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF Jr, Lynch KR, George SR (Apr 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes".Gene.187 (1):75–81.doi:10.1016/S0378-1119(96)00722-6.PMID 9073069.
^"Entrez Gene: GPR22 G protein-coupled receptor 22".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003)."Human chromosome 7: DNA sequence and biology".Science.300 (5620):767–72.Bibcode:2003Sci...300..767S.doi:10.1126/science.1083423.PMC 2882961.PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003)."The DNA sequence of human chromosome 7".Nature.424 (6945):157–64.Bibcode:2003Natur.424..157H.doi:10.1038/nature01782.PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Lee J, Hever A, Willhite D, et al. (2006)."Effects of RNA degradation on gene expression analysis of human postmortem tissues".FASEB J.19 (10):1356–8.doi:10.1096/fj.04-3552fje.PMID 15955843.S2CID 3200625.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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