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GPR182

From Wikipedia, the free encyclopedia
Protein-coding gene in humans
GPR182
Identifiers
AliasesGPR182, 7TMR, ADMR, AM-R, AMR, G10D, gamrh, hrhAMR, G protein-coupled receptor 182, L1-R
External IDsOMIM:605307;MGI:109545;HomoloGene:5255;GeneCards:GPR182;OMA:GPR182 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for GPR182
Genomic location for GPR182
Band12q13.3Start56,994,492bp[1]
End56,998,447bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for GPR182
Genomic location for GPR182
Band10 D3|10 75.07 cMStart127,583,145bp[2]
End127,587,601bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • spleen

  • sperm

  • tendon of biceps brachii

  • left adrenal cortex

  • right adrenal cortex

  • tibialis anterior muscle

  • liver

  • right testis

  • left testis
Top expressed in
  • yolk sac

  • atrium

  • mesenteric lymph nodes

  • right lung

  • liver

  • left lobe of liver

  • right lung lobe

  • endocardial cushion

  • left lung lobe

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11318

11536

Ensembl

ENSG00000166856

ENSMUSG00000058396

UniProt

O15218

P43142

RefSeq (mRNA)

NM_007264

NM_007412

RefSeq (protein)

NP_009195

NP_031438

Location (UCSC)Chr 12: 56.99 – 57 MbChr 10: 127.58 – 127.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GPR182 (orG protein-coupled receptor 182) is a human gene (and associated protein) which is anorphanG-protein coupled receptor.[5]

When this gene was first cloned, it was proposed to encode anadrenomedullin receptor.[6] However, when the corresponding protein was expressed, it was found not to respond toadrenomedullin (ADM).[7]

It was subsequently shown that a different GPCR,CALCRL when complexed withRAMP2 can function as an ADM receptor.[8]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000166856Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000058396Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (April 2003)."The G protein-coupled receptor repertoires of human and mouse".Proc. Natl. Acad. Sci. U.S.A.100 (8):4903–4908.Bibcode:2003PNAS..100.4903V.doi:10.1073/pnas.0230374100.PMC 153653.PMID 12679517.
  6. ^Hänze J, Dittrich K, Dötsch J, Rascher W (November 1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system".Biochem. Biophys. Res. Commun.240 (1):183–188.doi:10.1006/bbrc.1997.7631.PMID 9367907.
  7. ^Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (March 1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response".Biochem. Biophys. Res. Commun.244 (3):832–837.doi:10.1006/bbrc.1998.8349.PMID 9535752.
  8. ^McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor".Nature.393 (6683):333–339.Bibcode:1998Natur.393..333M.doi:10.1038/30666.PMID 9620797.S2CID 4364526.

Further reading

[edit]

External links

[edit]
  • "GPR182".IUPHAR GPCR Database. International Union of Pharmacology (IUPHAR). 2007-12-04. Archived fromthe original on 2008-06-07. Retrieved2008-07-03.
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