When this gene was first cloned, it was proposed to encode anadrenomedullin receptor.[6] However, when the corresponding protein was expressed, it was found not to respond toadrenomedullin (ADM).[7]
It was subsequently shown that a different GPCR,CALCRL when complexed withRAMP2 can function as an ADM receptor.[8]
^Hänze J, Dittrich K, Dötsch J, Rascher W (November 1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system".Biochem. Biophys. Res. Commun.240 (1):183–188.doi:10.1006/bbrc.1997.7631.PMID9367907.
^Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (March 1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response".Biochem. Biophys. Res. Commun.244 (3):832–837.doi:10.1006/bbrc.1998.8349.PMID9535752.
^McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor".Nature.393 (6683):333–339.Bibcode:1998Natur.393..333M.doi:10.1038/30666.PMID9620797.S2CID4364526.
Fowler DE, Wang P (2002). "The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review)".Int. J. Mol. Med.9 (5):443–9.doi:10.3892/ijmm.9.5.443.PMID11956648.
Kato J, Kitamura K, Kangawa K, Eto T (1995). "Receptors for adrenomedullin in human vascular endothelial cells".Eur. J. Pharmacol.289 (2):383–385.doi:10.1016/0922-4106(95)90117-5.PMID7621913.
Hänze J, Dittrich K, Dötsch J, Rascher W (1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system".Biochem. Biophys. Res. Commun.240 (1):183–188.doi:10.1006/bbrc.1997.7631.PMID9367907.
Kennedy SP, Sun D, Oleynek JJ, et al. (1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response".Biochem. Biophys. Res. Commun.244 (3):832–837.doi:10.1006/bbrc.1998.8349.PMID9535752.
Forneris M, Gottardo L, Albertin G, et al. (2002). "Expression and function of adrenomedullin and its receptors in Conn's adenoma cells".Int. J. Mol. Med.8 (6):675–9.doi:10.3892/ijmm.8.6.675.PMID11712085.
Hänze J, Groneberg DA, Rose F, et al. (2002). "Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia".Biochem. Biophys. Res. Commun.291 (5):1160–1165.doi:10.1006/bbrc.2002.6595.PMID11883938.
Chosa E, Hamada H, Kitamura K, et al. (2003). "Expression of adrenomedullin and its receptor by chondrocyte phenotype cells".Biochem. Biophys. Res. Commun.303 (1):379–386.doi:10.1016/S0006-291X(03)00347-4.PMID12646214.
Xu P, Dai AG, Zhou HD, et al. (2004). "[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease]".Zhonghua Jie He He Hu Xi Za Zhi.26 (12):765–8.PMID14720432.