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GPR179

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GPR179
Identifiers
AliasesGPR179, CSNB1E, GPR158L, GPR158L1, G protein-coupled receptor 179
External IDsOMIM:614515;MGI:2443409;HomoloGene:34917;GeneCards:GPR179;OMA:GPR179 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for GPR179
Genomic location for GPR179
Band17q12Start38,324,571bp[1]
End38,343,956bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for GPR179
Genomic location for GPR179
Band11|11 DStart97,222,935bp[2]
End97,242,903bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • prefrontal cortex

  • superior frontal gyrus

  • sural nerve

  • primary visual cortex

  • Brodmann area 9

  • skeletal muscle tissue

  • Hypothalamus

  • right frontal lobe

  • nucleus accumbens
Top expressed in
  • neural layer of retina

  • vestibular sensory epithelium

  • epithelium of lens

  • Hypothalamus

  • left ventricle

  • diencephalic nucleus

  • aortic valve

  • nucleus of hypothalamus

  • adrenal gland

  • islet of Langerhans
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

440435

217143

Ensembl

ENSG00000276469
ENSG00000277399

ENSMUSG00000070337

UniProt

Q6PRD1

E9PY61

RefSeq (mRNA)

NM_001004334

NM_001081220
NM_175453

RefSeq (protein)

NP_001004334

NP_001074689

Location (UCSC)Chr 17: 38.32 – 38.34 MbChr 11: 97.22 – 97.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 179 is aprotein that in humans is encoded by theGPR179gene.[5]

Clinical relevance

[edit]

Mutations in this gene have been associated to cases of congenital stationaryNight Blindness.[6]

References

[edit]
  1. ^abcENSG00000277399 GRCh38: Ensembl release 89: ENSG00000276469, ENSG00000277399 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000070337 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: GPR179 G protein-coupled receptor 179".
  6. ^Audo I, Bujakowska K, Orhan E, Poloschek CM, Defoort-Dhellemmes S, Drumare I, Kohl S, Luu TD, Lecompte O, Zrenner E, Lancelot ME, Antonio A, Germain A, Michiels C, Audier C, Letexier M, Saraiva JP, Leroy BP, Munier FL, Mohand-Saïd S, Lorenz B, Friedburg C, Preising M, Kellner U, Renner AB, Moskova-Doumanova V, Berger W, Wissinger B, Hamel CP, Schorderet DF, De Baere E, Sharon D, Banin E, Jacobson SG, Bonneau D, Zanlonghi X, Le Meur G, Casteels I, Koenekoop R, Long VW, Meire F, Prescott K, de Ravel T, Simmons I, Nguyen H, Dollfus H, Poch O, Léveillard T, Nguyen-Ba-Charvet K, Sahel JA, Bhattacharya SS, Zeitz C (Feb 10, 2012)."Whole-Exome Sequencing Identifies Mutations in GPR179 Leading to Autosomal-Recessive Complete Congenital Stationary Night Blindness".American Journal of Human Genetics.90 (2):321–30.doi:10.1016/j.ajhg.2011.12.007.PMC 3276675.PMID 22325361.

Further reading

[edit]
  • Bjarnadóttir TK, Fredriksson R, Schiöth HB (2006). "The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors".Gene.362:70–84.doi:10.1016/j.gene.2005.07.029.PMID 16229975.
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