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GPLD1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GPLD1
Identifiers
AliasesGPLD1, GPIPLD, GPIPLDM, PIGPLD, PIPLD, glycosylphosphatidylinositol specific phospholipase D1
External IDsOMIM:602515;MGI:106604;HomoloGene:1152;GeneCards:GPLD1;OMA:GPLD1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for GPLD1
Genomic location for GPLD1
Band6p22.3Start24,424,565bp[1]
End24,495,205bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for GPLD1
Genomic location for GPLD1
Band13 A3.1|13 10.79 cMStart25,127,135bp[2]
End25,176,484bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • human penis

  • liver

  • buccal mucosa cell

  • right lobe of liver

  • right hemisphere of cerebellum

  • skin of thigh

  • testicle

  • gonad

  • Descending thoracic aorta
Top expressed in
  • left lobe of liver

  • utricle

  • dorsal tegmental nucleus

  • dorsomedial hypothalamic nucleus

  • transitional epithelium of urinary bladder

  • mammillary body

  • arcuate nucleus

  • paraventricular nucleus of hypothalamus

  • esophagus

  • lumbar subsegment of spinal cord
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2822

14756

Ensembl

ENSG00000112293

ENSMUSG00000021340

UniProt

P80108

O70362

RefSeq (mRNA)

NM_001503
NM_177483

NM_008156

RefSeq (protein)

NP_001494

n/a

Location (UCSC)Chr 6: 24.42 – 24.5 MbChr 13: 25.13 – 25.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol-glycan-specific phospholipase D is anenzyme that in humans is encoded by theGPLD1gene.[5][6]

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by aglycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by the GPLD1 gene is a GPI degrading enzyme thathydrolyzes the inositol phosphate linkage in proteins anchored byphosphatidylinositol glycans, thereby releasing the attached protein from theplasma membrane.[6]

Plasma concentrations of Gpld1 in mice were found to increase after exercise and to correlate with improvedcognitive function, and concentrations of GPLD1 in blood were increased in active elderly humans.[7][8]

Interactions

[edit]

GPLD1 has been shown tointeract withApolipoprotein A1[9] andAPOA4.[9]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000112293Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000021340Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Schofield JN, Rademacher TW (November 2000). "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1494 (1–2):189–94.doi:10.1016/s0167-4781(00)00194-9.PMID 11072085.
  6. ^ab"Entrez Gene: GPLD1 glycosylphosphatidylinositol specific phospholipase D1".
  7. ^Horowitz AM, Fan X, Bieri G, Smith LK, Sanchez-Diaz CI, Schroer AB, et al. (July 2020)."Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain".Science.369 (6500):167–173.Bibcode:2020Sci...369..167H.doi:10.1126/science.aaw2622.PMC 7879650.PMID 32646997.S2CID 220428681.
  8. ^Harris R (9 June 2020)."An Enzyme That Increases With Exercise Can Improve Memory In Mice, And Maybe People".National Public Radio.
  9. ^abDeeg MA, Bierman EL, Cheung MC (March 2001)."GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex".Journal of Lipid Research.42 (3):442–51.doi:10.1016/S0022-2275(20)31669-2.PMID 11254757.

Further reading

[edit]


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