The receptor for gonadotropin-releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembraneG protein-coupled receptor. However, in humans, theN-terminus of the predicted protein contains a frameshift and premature stop codon. In humans, GnRHR2 transcription occurs but whether the gene produces a functionalC-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribedpseudogene of GnRHR2 is also on chromosome 14.[4]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Faurholm B, Millar RP, Katz AA (Nov 2001). "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci".Genomics.78 (1–2):15–8.doi:10.1006/geno.2001.6650.PMID11707068.
Neill JD, Duck LW, Sellers JC, Musgrove LC (2001). "A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates".Biochem. Biophys. Res. Commun.282 (4):1012–8.doi:10.1006/bbrc.2001.4678.PMID11352653.
Eicke N, Günthert AR, Viereck V, et al. (2005). "GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs".Eur. J. Endocrinol.153 (4):605–12.doi:10.1530/eje.1.02005.PMID16189182.
