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GNG7

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GNG7

Identifiers

Aliases

GNG7, G protein subunit gamma 7, HG3B

External IDs

OMIM:604430;MGI:95787;HomoloGene:31293;GeneCards:GNG7;OMA:GNG7 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	2,511,219bp^[1]
Band	19p13.3	End	2,702,694bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 C1\|10 39.72 cM	Start	80,784,458bp^[2]
Band	10 C1\|10 39.72 cM	End	80,850,779bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

nucleus accumbens

caudate nucleus

putamen

inferior ganglion of vagus nerve

external globus pallidus

C1 segment

ventral tegmental area

subthalamic nucleus

superior vestibular nucleus

amygdala

Top expressed in

olfactory tubercle

nucleus accumbens

globus pallidus

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

primary visual cortex

subiculum

hippocampus proper

temporal lobe

amygdala

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	signal transducer activity GTPase activity G-protein beta-subunit binding
Cellular component	heterotrimeric G-protein complex plasma membrane extracellular exosome membrane G-protein beta/gamma-subunit complex
Biological process	G protein-coupled receptor signaling pathway cellular response to glucagon stimulus regulation of G protein-coupled receptor signaling pathway signal transduction behavioral fear response receptor guanylyl cyclase signaling pathway locomotory behavior regulation of adenylate cyclase activity
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2788


14708

Ensembl


ENSG00000176533


ENSMUSG00000048240

UniProt


O60262


Q61016

RefSeq (mRNA)


NM_052847


NM_001038655 NM_010319

RefSeq (protein)


NP_443079


NP_001033744 NP_034449 NP_001393192 NP_001393193

Location (UCSC)

Chr 19: 2.51 – 2.7 Mb

Chr 10: 80.78 – 80.85 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 is aprotein that in humans is encoded by theGNG7gene.^[5]^[6]

Interactions

[edit]

GNG7 has been shown tointeract withGNB5.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000176533 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000048240 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Shibata K, Mori M, Tanaka S, Kitano S, Akiyoshi T (Jun 1998). "Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer".Biochem. Biophys. Res. Commun.246 (1):205–9.Bibcode:1998BBRC..246..205S.doi:10.1006/bbrc.1998.8581.PMID 9600093.
^"Entrez Gene: GNG7 guanine nucleotide binding protein (G protein), gamma 7".
^Yan K, Kalyanaraman V, Gautam N (Mar 1996)."Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families".J. Biol. Chem.271 (12):7141–6.doi:10.1074/jbc.271.12.7141.PMID 8636150.

Ueda N, Iñiguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG (1994)."G protein beta gamma subunits. Simplified purification and properties of novel isoforms".J. Biol. Chem.269 (6):4388–95.doi:10.1016/S0021-9258(17)41792-3.PMID 8308009.
Yan K, Kalyanaraman V, Gautam N (1996)."Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families".J. Biol. Chem.271 (12):7141–6.doi:10.1074/jbc.271.12.7141.PMID 8636150.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.

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Intracellular signaling peptides and proteins

MAP

seeMAP kinase pathway

Calcium

G protein

Heterotrimeric

cAMP:	Heterotrimeric G protein Gs/Gi Adenylate cyclase cAMP 3',5'-cyclic-AMP phosphodiesterase Protein kinase A
cGMP:	Transducin Gustducin Guanylate cyclase cGMP 3',5'-cyclic-GMP phosphodiesterase Protein kinase G
G alpha subunit G_α GNAO1 GNAI1 GNAI2 GNAI3 GNAT1 GNAT2 GNAT3 GNAZ GNAS GNAL GNAQ GNA11 GNA12 GNA13 GNA14 GNA15/GNA16
G beta-gamma complex G_β GNB1 GNB2 GNB3 GNB4 GNB5 G_γ GNGT1 GNGT2 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG10 GNG11 GNG12 GNG13 BSCL2
G protein-coupled receptor kinase AMP-activated protein kinase

Monomeric

Cyclin

Lipid

Otherprotein kinase

Serine/threonine:	Casein kinase 1 2 eIF-2 kinase EIF2AK3 Glycogen synthase kinase GSK1 GSK2 GSK-3 GSK3A GSK3B IκB kinase CHUK IKK2 IKBKG Interleukin-1 receptor associated kinase IRAK1 IRAK2 IRAK3 IRAK4 Lim kinase LIMK1 LIMK2 p21-activated kinases PAK1 PAK2 PAK3 PAK4 Rho-associated protein kinase ROCK1 ROCK2 Ribosomal s6 kinase RPS6KA1
Tyrosine:	ZAP70 Focal adhesion protein-tyrosine kinase PTK2 PTK2B BTK
Serine/threonine/tyrosine	Dual-specificity kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4
Arginine	Arginine kinase McsB

Otherprotein phosphatase

Serine/threonine:	Protein phosphatase 2
Tyrosine:	protein tyrosine phosphatase:Receptor-like protein tyrosine phosphatase Sh2 domain-containing protein tyrosine phosphatase
both:	Dual-specificity phosphatase