Growth differentiation factor 6 (GDF6) is aprotein that in humans is encoded by theGDF6gene.[5]
GDF6 belongs to thetransforming growth factor beta superfamily and may regulate patterning of theectoderm by interacting withbone morphogenetic proteins,[6] and control eye development.[7][8]
Growth differentiation factor 6 (GDF6) is a regulatory protein associated with growth and differentiation of developing embryos. GDF6 is encoded by the GDF6 gene. It is a member the transforming growth factor beta superfamily which is a group of proteins involved in early regulation of cell growth and development. GDF6 has been shown to play an important role in the patterning of theepidermis[9] and bone and joint formation.[10] GDF6 induces genes related to the development of the epidermis and can bind directly tonoggin, a gene that controls neural development, to block its effect.[9] GDF6 interacts withbone morphogenetic proteins (BMPs) to form heterodimers that may work to regulate neural induction and patterning in developing embryos.[9] By developing a GDF6 “knockout” model, scientists repressed expression of GDF6 in developing mice embryos. Through this experiment, the scientists were able to directly link GDF6 with several skull and vertebral joint disorders, such asscoliosis andchondrodysplasia, Grebe type.[10]
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