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GD-42

From Wikipedia, the free encyclopedia
Chemical compound
GD-42
Names
Preferred IUPAC name
4,8-Dimethyl-4-oxo-3-oxa-5,8-dithia-4λ5-phosphadecan-8-ium methyl sulfate
Other names
Methylsulfomethylate
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C8H20O2PS2.CH4O4S/c1-5-10-11(3,9)12-7-8-13(4)6-2;1-5-6(2,3)4/h5-8H2,1-4H3;1H3,(H,2,3,4)/q+1;/p-1
    Key: AUACWHVUVIIDOR-UHFFFAOYSA-M
  • CCOP(=O)(C)SCC[S+](C)CC.COS(=O)(=O)[O-]
Properties
C9H23O6PS3
Molar mass354.43 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

GD-42 (methylsulfomethylate) is an irreversibleacetylcholinesterase inhibitor.[1][2] It has a positively chargedsulfonium group.

See also

[edit]

References

[edit]
  1. ^Danilov, AF; Kvitko, IJ; Lavrentieva, VV; Michelson, MJ; Porai-Koshits, BA; Rozhkova, EK; Shelkovnikov, SA (April 1972)."Action of some bisquaternary derivatives of phthalic acids and related substances on neuromuscular transmission".British Journal of Pharmacology.44 (4):765–78.doi:10.1111/j.1476-5381.1972.tb07314.x.PMC 1665980.PMID 4339387.
  2. ^Danilov, AF; Ivanov, YJ; Michelson, MJ (January 1976)."The influence of motor nerve tetanization on the effect of organophosphorus cholinesterase inhibitors on neuromuscular transmission".British Journal of Pharmacology.56 (1):115–23.doi:10.1111/j.1476-5381.1976.tb06966.x.PMC 1666757.PMID 175873.
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
Release
(modulators)
Inhibitors
Enhancers
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