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GABPB2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GABPB1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1AWC

Identifiers
AliasesGABPB1, BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB2, NRF2B1, NRF2B2, GABPB-1, GA binding protein transcription factor beta subunit 1, GA binding protein transcription factor subunit beta 1
External IDsOMIM:600610;MGI:95611;HomoloGene:7723;GeneCards:GABPB1;OMA:GABPB1 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for GABPB1
Genomic location for GABPB1
Band15q21.2Start50,275,389bp[1]
End50,355,408bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for GABPB1
Genomic location for GABPB1
Band2 F1|2 61.76 cMStart126,469,362bp[2]
End126,518,257bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • cartilage tissue

  • bone marrow cells

  • ventricular zone

  • ganglionic eminence

  • Achilles tendon

  • stromal cell of endometrium

  • testicle

  • gonad

  • lactiferous duct
Top expressed in
  • tail of embryo

  • ventricular zone

  • granulocyte

  • genital tubercle

  • thymus

  • ganglionic eminence

  • epiblast

  • spermatid

  • embryo

  • primary oocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2553

14391

Ensembl

ENSG00000104064

ENSMUSG00000027361

UniProt

Q06547

Q00420

RefSeq (mRNA)
NM_002041
NM_005254
NM_016654
NM_016655
NM_181427

NM_001320910
NM_001320915

NM_001271467
NM_001271468
NM_001271469
NM_001271470
NM_001271492

NM_010249
NM_207669
NM_001355108
NM_001355109

RefSeq (protein)
NP_001307839
NP_001307844
NP_002032
NP_005245
NP_057738

NP_057739
NP_852092
NP_057738.1

NP_001258396
NP_001258397
NP_001258398
NP_001258399
NP_001258421

NP_034379
NP_997552
NP_001342037
NP_001342038
NP_001393121
NP_001393122
NP_001393123
NP_001393124
NP_001393125
NP_001393126
NP_001393127
NP_001393128
NP_001393129
NP_001393130
NP_001393131
NP_001393132
NP_001393133
NP_001393134
NP_001393135
NP_001393136
NP_001393137
NP_001393138
NP_001393139
NP_001393140
NP_001393141
NP_001393142
NP_001393143
NP_001393144
NP_001393145
NP_001393146
NP_001393147
NP_001393148
NP_001393149
NP_001393150
NP_001393151
NP_001393152
NP_001393153
NP_001393154
NP_001393155
NP_001393156

Location (UCSC)Chr 15: 50.28 – 50.36 MbChr 2: 126.47 – 126.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GA-binding protein subunit beta-1 is aprotein that in humans is encoded by theGABPB1gene.[5][6]

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000104064Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000027361Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^de la Brousse FC, Birkenmeier EH, King DS, Rowe LB, McKnight SL (Nov 1994)."Molecular and genetic characterization of GABP beta".Genes Dev.8 (15):1853–65.doi:10.1101/gad.8.15.1853.PMID 7958862.
  6. ^ab"Entrez Gene: GABPB2 GA binding protein transcription factor, beta subunit 2".

Further reading

[edit]

External links

[edit]
PDB gallery
  • 1awc: MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA
    1awc: MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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