GA-binding protein alpha chain is aprotein that in humans is encoded by theGABPAgene.[5]
This gene encodes one of three GA-binding proteintranscription factorsubunits which functions as aDNA-binding subunit. Since this subunit shares identity with a subunit encoding thenuclear respiratory factor 2 gene, it is likely involved in activation ofcytochrome c oxidaseexpression and nuclear control ofmitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of theadenovirus E4 gene. Because of its chromosomal localization and ability to formheterodimers with otherpolypeptides, this gene may play a role in theDown syndromephenotype.[6]
GABPA has been shown tointeract withHost cell factor C1,[7]Sp1 transcription factor[8] andSp3 transcription factor.[8]
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