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| Clinical data | |
|---|---|
| Other names | [18F]Fluorothymidine;18F-3'-Fluoro-3'-deoxythymidine;18F-FLT;18F-alovudine |
| Identifiers | |
| CAS Number | |
| UNII | |
| CompTox Dashboard(EPA) | |
| Chemical and physical data | |
| Formula | C10H13FN2O4 |
| Molar mass | 244.222 g·mol−1 |
| 3D model (JSmol) | |
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Fluorothymidine F-18 (FLT) is atumor-specificPET tracer andradiopharmaceutical. It is anisotopologue ofalovudine. FLT is suitable for monitoring how tumors respond tocytostatic therapy. FLT accumulates inproliferating cells where it indicates the activity of the enzymethymidine kinase.Cell division can be characterized by the activity of that enzyme. FLT isphosphorylated as though it werethymidine, and is subsequently incorporated intoDNA. Thymidine is essential for DNA replication. Considering that FLT lacks a 3′-hydroxy group,transcription of DNA is impeded following incorporating of FLT. FLT indicates changes in tumor cell proliferation by tracking the restoration ofnucleosides from degenerated DNA.[1]
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