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Fluorolintane

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Fluorolintane
Legal status
Legal status
Identifiers
  • 1-(1-(2-Fluorophenyl)-2-phenylethyl)pyrrolidine
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC18H20FN
Molar mass269.363 g·mol−1
3D model (JSmol)
  • FC1=C(C=CC=C1)C(CC2=CC=CC=C2)N3CCCC3
  • InChI=1S/C18H20FN/c19-17-11-5-4-10-16(17)18(20-12-6-7-13-20)14-15-8-2-1-3-9-15/h1-5,8-11,18H,6-7,12-14H2
  • Key:ZAGWVXYVNFPCLW-UHFFFAOYSA-N

Fluorolintane (also known as2-FPPP and2-F-DPPy) is adissociativeanesthetic drug that has been sold online as adesigner drug.[1][2][3][4]

Fluorolintane and related diarylethylamines areantagonists of theNMDA receptor[5] and have been studiedin vitro as potential treatments forneurotoxic injury,[6]depression[7] and assympathomimetic.[8]

See also

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References

[edit]
  1. ^Wallach J, Kavanagh PV, McLaughlin G, Morris N, Power JD, Elliott SP, et al. (May 2015)."Preparation and characterization of the 'research chemical' diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers"(PDF).Drug Testing and Analysis.7 (5):358–367.doi:10.1002/dta.1689.PMID 25044512.
  2. ^"Analytical Report - Fluorolintane"(PDF). Nacionalni forenzični laboratorij (NFL). January 2016.
  3. ^Wallach J, Colestock T, Agramunt J, Claydon MD, Dybek M, Filemban N, et al. (August 2019)."Pharmacological characterizations of the 'legal high' fluorolintane and isomers".European Journal of Pharmacology.857 172427.doi:10.1016/j.ejphar.2019.172427.PMC 6899220.PMID 31152702.
  4. ^Dybek M, Wallach J, Kavanagh PV, Colestock T, Filemban N, Dowling G, et al. (August 2019). "Syntheses and analytical characterizations of the research chemical 1-[1-(2-fluorophenyl)-2-phenylethyl]pyrrolidine (fluorolintane) and five of its isomers".Drug Testing and Analysis.11 (8):1144–1161.doi:10.1002/dta.2608.PMID 31033229.S2CID 139103681.
  5. ^Berger ML, Schweifer A, Rebernik P, Hammerschmidt F (May 2009). "NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds".Bioorganic & Medicinal Chemistry.17 (9):3456–62.doi:10.1016/j.bmc.2009.03.025.PMID 19345586.
  6. ^Gray NM, Cheng BK (1994)."Patent EP 0346791 B1 - 1,2-diarylethylamines for treatment of neurotoxic injury".
  7. ^Aspergren BD, Heinzelman RV (1963)."Patent US 3083139 A - Therapeutic 1-(1, 2-diphenylethyl) pyrrolidine for the management of depression".
  8. ^Heinzelman RV, Aspergren BD (July 1953). "Compounds Containing the Pyrrolidine Ring. Analogs of Sympathomimetic Amines".Journal of the American Chemical Society.75 (14):3409–3413.Bibcode:1953JAChS..75.3409H.doi:10.1021/ja01110a033.
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
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