 | |
.png) | |
| Clinical data | |
|---|---|
| Trade names | Synalar, others |
| AHFS/Drugs.com | Monograph Monograph |
| Pregnancy category |
|
| Routes of administration | Topical, ophthalmic intravitreal injection |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Metabolism | Liver,CYP3A4-mediated |
| Eliminationhalf-life | 1.3 to 1.7 hours |
| Identifiers | |
| |
| CAS Number |
|
| PubChemCID | |
| IUPHAR/BPS | |
| DrugBank |
|
| ChemSpider |
|
| UNII | |
| KEGG |
|
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.000.607 |
| Chemical and physical data | |
| Formula | C24H30F2O6 |
| Molar mass | 452.495 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
 N Y (what is this?) (verify) | |
Fluocinolone acetonide is a fluorinatedcorticosteroid primarily used indermatology to reduce skin inflammation and relieve itching.[2] It is a synthetichydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City.[3] Preparations containing it were first marketed under the brand nameSynalar.
Fluocinolone acetonide was also found to strongly potentiate TGF-β-associatedchondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.[4]
Fluocinolone acetonideintravitreal implants have been used to treat non-infectiousuveitis. A systematic review could not determine with any confidence whether fluocinolone acetonide implants are superior to standard of care treatment for uveitis.[5] A fluocinolone acetonide intravitreal implant with the brand name Iluvien is sold by biopharmaceutical companyAlimera Sciences to treatdiabetic macular edema.[6]
It was approved for medical use in 1961.[7]
 | This sectiondoes notcite anysources. Please helpimprove this section byadding citations to reliable sources. Unsourced material may be challenged andremoved.(July 2024) (Learn how and when to remove this message) |
Fluocinolone is a group V (0.025%) or group VI (0.01%)corticosteroid under US classification.
Fluocinolone acetonide is available under the brand names Flucort-N, Iluvien, Synalar, Yutiq,[8] and others.[2][9]
{{cite journal}}: CS1 maint: overridden setting (link)