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Flunitrazolam

From Wikipedia, the free encyclopedia
Triazolobenzodiazepine drug
Pharmaceutical compound
Flunitrazolam
Legal status
Legal status
Identifiers
  • 1-methyl-8-nitro-6-(2-fluorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.439.381Edit this at Wikidata
Chemical and physical data
FormulaC17H12FN5O2
Molar mass337.314 g·mol−1
3D model (JSmol)
  • O=[N](=O)c4ccc2-n1c(C)nnc1CN=C(c2c4)c3ccccc3F
  • InChI=1S/C17H12FN5O2/c1-10-20-21-16-9-19-17(12-4-2-3-5-14(12)18)13-8-11(23(24)25)6-7-15(13)22(10)16/h2-8H,9H2,1H3
  • Key:RDLAGIOILLWVTM-UHFFFAOYSA-N

Flunitrazolam (FNTZ,Flunazolam) is atriazolobenzodiazepine (TBZD), which arebenzodiazepine (BZD) derivatives, that has been sold online as adesigner drug, and is a potenthypnotic andsedative drug similar to related compounds such asflunitrazepam,clonazolam andflubromazolam. It was first definitively identified and reported to theEMCDDA Early Warning System, by an analytical laboratory in Germany in October 2016,[2] and had not been described in the scientific or patent literature before this.[3] It is the triazole analogue ofFlunitrazepam (Rohypnol). The addition of thetriazole ring to the scaffold increases potency significantly, this is evident as flunitrazolam is reported anecdotally to be active in themicrogram level.[4][5] It is active at 0.1 mg.

See also

[edit]

References

[edit]
  1. ^Anvisa (2024-05-28)."RDC Nº 877 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 877 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União.Archived from the original on 2024-09-25. Retrieved2024-09-25.
  2. ^"Europol 2016 Annual Report on the implementation of Council Decision 2005/387/JHA"(PDF).
  3. ^Cornett EM, Novitch MB, Brunk AJ, Davidson KS, Menard BL, Urman RD, Kaye AD (June 2018). "New benzodiazepines for sedation".Best Practice & Research. Clinical Anaesthesiology.32 (2):149–164.doi:10.1016/j.bpa.2018.06.007.PMID 30322456.S2CID 53501694.
  4. ^Ameline A, Richeval C, Gaulier JM, Raul JS, Kintz P (July 2018)."Characterization of Flunitrazolam, a New Designer Benzodiazepine, in Oral Fluid After a Controlled Single Administration".Journal of Analytical Toxicology.42 (6):e58 –e60.doi:10.1093/jat/bky012.PMID 29462316.
  5. ^Ameline A, Richeval C, Gaulier JM, Raul JS, Kintz P (February 2019). "Detection of the designer benzodiazepine flunitrazolam in urine and preliminary data on its metabolism".Drug Testing and Analysis.11 (2):223–229.doi:10.1002/dta.2480.PMID 30109775.S2CID 52001932.
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