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Flumetasone pivalate

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Flumetasone pivalate
Clinical data
Other namesFlumetasone 21-pivalate
Drug classCorticosteroid;Glucocorticoid
Identifiers
  • (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-(2,2-dimethylpropionyl)oxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChemCID
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.016.275Edit this at Wikidata
Chemical and physical data
FormulaC27H36F2O6
Molar mass494.576 g·mol−1
3D model (JSmol)
  • C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C(C)(C)C)O)C)O)F)C)F
  • InChI=1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1
  • Key:JWRMHDSINXPDHB-OJAGFMMFSA-N

Flumetasone pivalate is asyntheticglucocorticoidcorticosteroid and acorticosteroid ester. It is the 21-acetate ester offlumetasone.[1][2][3]

References

[edit]
  1. ^A Sayed R, Mohamed AR, Hassan WS, Elmasry MS (June 2021). "Comparative study of novel green UV-spectrophotometric platforms for simultaneous rapid analysis of flumethasone pivalate and clioquinol in their combined formulation".Drug Development and Industrial Pharmacy.47 (6):867–877.doi:10.1080/03639045.2021.1908341.PMID 34224277.S2CID 235746754.
  2. ^"Flumethasone pivalate (Locorten). Anti-inflammatory, antipruritic".Clinical Pharmacology and Therapeutics.11 (6):927–929. 1970-11-06.doi:10.1002/cpt1970116927.PMID 5481576.S2CID 126851.
  3. ^Hopkała H, Przyborowski L (June 1988). "Determination of drugs containing fluorine with ion-selective electrode. Part 1: Synthetic glucocorticosteroids".Die Pharmazie.43 (6):422–423.PMID 3212030.
GRTooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
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