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| Clinical data | |
|---|---|
| Trade names | Cronolone, others |
| Other names | Flurogestone acetate; Fluorogestone acetate; FGA; NSC-65411; SC-9880; 17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone |
| Routes of administration | Intravaginal |
| Drug class | Progestogen;Progestin;Progestogen ester |
| Identifiers | |
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| CAS Number | |
| PubChemCID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.017.979 |
| Chemical and physical data | |
| Formula | C23H31FO5 |
| Molar mass | 406.494 g·mol−1 |
| 3D model (JSmol) | |
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Flugestone acetate (FGA), sold under the brand nameCronolone among others, is aprogestin medication which is used inveterinary medicine.[1][2][3][4][5][6]
FGA is used as anintravaginalsponge preparation to synchronizeestrus inewes andgoats.[2][4][5][6]
FGA, also known as 17α-acetoxy-9α-fluoro-11β-hydroxyprogesterone or as 17α-acetoxy-9α-fluoro-11β-hydroxypregn-4-ene-3,20-dione, is asyntheticpregnanesteroid and aderivative ofprogesterone and17α-hydroxyprogesterone.[1][3] It is the C17αacetateester offlugestone.[1][3][2]
FGA was developed and marketed byG.D. Searle & Company in the 1960s.[7][8]
Flugestone acetate is thegeneric name of the drug and itsINNTooltip International Nonproprietary Name andBANMTooltip British Approved Name, whileflurogestone acetate is itsUSANTooltip United States Adopted Name.[1][3][2][9]Flugestone is theBANTooltip British Approved Name andDCITTooltip Denominazione Comune Italiana of the unesterified free alcohol form.[1][3][2][9] FGA is also known by its developmental code namesNSC-65411 andSC-9880.[1][3][2][9]
FGA is or has been marketed under the brand names Chronogest, Chrono-Gest, Crono-Gest, Cronolone, Gyncro-Mate, Ova-Gest, Ovakron, Synchro-Mate, Syncro Part, and Syncropart.[1][3][2][9]
FGA is marketed for veterinary use inAustralia,France,Ireland,Israel,Italy, theNetherlands,South Africa, and theUnited Kingdom.[3][9]