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| Clinical data | |
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| Trade names | Nuflor |
| Other names | 2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)ethanamide |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Intramuscular,subcutaneous |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.170.898 |
| Chemical and physical data | |
| Formula | C12H14Cl2FNO4S |
| Molar mass | 358.21 g·mol−1 |
| 3D model (JSmol) | |
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Florfenicol (marketed bySchering-Plough Animal Health under the brand name Nuflor) is a fluorinated synthetic analog ofthiamphenicol,[1] mainly used as aantibiotic inveterinary medicine.
Florfenicol is available ageneric medication.[2]
In the United States, florfenicol isindicated for the treatment ofbovine respiratory disease (BRD) associated withMannheimia haemolytica,Pasteurella multocida, andHistophilus somni, for treatment of bovine interdigitalphlegmon (foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated withFusobacterium necrophorum andPrevotella melaninogenica.
In swine, it is indicated for the treatment of respiratory infections caused byActinobacillus pleuropneumoniae,Bordetella bronchiseptica,Glaesserella parasuis,P. multocida, andStreptococcus suis.
Florfenicol is also used inaquaculture, and is licensed for use in the United States for the control of enteric septicemia incatfish.[3]
Since the early 2000s, it has been used in the Europe Union,[4] treating mainly primary or secondarycolibacillosis inbroiler[5] and parent flocks.
The use of florfenicol in horses, and likely in other equids, typically causes diarrhea. This has been anecdotally reported to progress to lethal cases of acute colitis. Therefore, use of this antimicrobial in the equine patient should be limited to cases in which other, safer, options are not available.[6]
In November 2024, the USFood and Drug Administration approved Paqflor (florfenicol), the first generic florfenicol drug for controlling mortality in certain species of freshwater-reared fish.[7] Paqflor contains the same active ingredient (florfenicol) as the approved brand name drug product, Aquaflor, which was first approved in October 2005.[7] In addition, the FDA determined that Paqflor contains no inactive ingredients that may significantly affect the bioavailability of the active ingredient.[7] Paqflor is indicated for freshwater-reared salmonids: for the control of mortality due to furunculosis associated withAeromonas salmonicida. For the control of mortality due to coldwater disease associated withFlavobacterium psychrophilum; freshwater-reared finfish: for the control of mortality due to columnaris disease associated withFlavobacterium columnare; catfish: for the control of mortality due to enteric septicemia of catfish associated withEdwardsiella ictaluri; freshwater-reared warmwater finfish: for the control of mortality due to streptococcal septicemia associated withStreptococcus iniae.[8][9]
Florfenicol was among the drug contaminants in a brand of supermarket eggs in Taiwan and Iran.[10]
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