Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Flavoxate

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Flavoxate
Clinical data
AHFS/Drugs.comMonograph
MedlinePlusa682706
ATC code
Identifiers
  • 2-(1-piperidyl)ethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate
CAS Number
PubChemCID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.035.745Edit this at Wikidata
Chemical and physical data
FormulaC24H25NO4
Molar mass391.467 g·mol−1
3D model (JSmol)
  • O=C(OCCN1CCCCC1)c4cccc2c4O/C(=C(\C2=O)C)c3ccccc3
  • InChI=1S/C24H25NO4/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25/h2,4-5,8-12H,3,6-7,13-16H2,1H3 checkY
  • Key:SPIUTQOUKAMGCX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Flavoxate is ananticholinergic withantimuscarinic effects. Itsmuscle relaxant properties may be due to a direct action on the smooth muscle rather than by antagonizing muscarinic receptors.

Clinical uses

[edit]

Flavoxate is used to treat urinary bladder spasms. It is available under the trade name Urispas (Paladin)(india), Genurin (by Recordati, Italy) in Italy and KSA, Uritac by El Saad company in Syria, under the name Bladderon byNippon Shinyaku of Japan, or Bladuril in Chile, Utispas ( Apex Pharma) in Nepal.

Flavoxate is indicated for symptomatic relief ofinterstitial cystitis, dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.

Side effects

[edit]

Flavoxate is generally well tolerated, but can potentially cause vomiting, upset stomach, dry mouth or throat, blurred vision, eye pain,[1] and increased sensitivity of the eyes to light.

Contraindications

[edit]

Flavoxate is contraindicated in patients who have any of the following obstructive conditions: pyloric or duodenal obstruction, obstructive intestinal lesions or ileus, achalasia, gastrointestinal hemorrhage and obstructive uropathies of the lower urinary tract.

References

[edit]
  1. ^Mohammed ZS, Simi ZU, Tariq SM, Ali KR (November 2008)."Bilateral acute angle closure glaucoma in a 50 year old female after oral administration of flavoxate".British Journal of Clinical Pharmacology.66 (5):726–7.doi:10.1111/j.1365-2125.2008.03254.x.PMC 2661991.PMID 18754848.

Further reading

[edit]
  • Brenner GN (2000).Pharmacology. Philadelphia, PA: W.B. Saunders Company.ISBN 0-7216-7757-6.
  • Canadian Pharmacists Association (2000).Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom.ISBN 0-919115-76-4.
  • "Flavoxate".PubMed Health. U.S. National Library of Medicine, National Institutes of Health. Archived fromthe original on October 17, 2010.
Urologicals, including antispasmodics (G04B)
Acidifiers
Urinaryantispasmodics
(primarilyantimuscarinics)
Other urologicals
Psychedelics
(5-HT2AR agonists)
  • For a full list of serotonergic psychedelics, see the navboxhere and the listhere instead.
Dissociatives
(NMDARantagonists)
Arylcyclo‐
hexylamines
Adamantanes
Diarylethylamines
Morphinans
Others
Deliriants
(mAChRantagonists)
Cannabinoids
(CB1R agonists)
Natural
Synthetic
AM-x
CPx
HU-x
JWH-x
Misc.
  •  For a full list of cannabinoids, see the navboxhere and the listhere instead.
κORagonists
GABAARagonists
Inhalants
(mixedMoATooltip mechanism of action)
Others
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(andprodrugs)
Retrieved from "https://en.wikipedia.org/w/index.php?title=Flavoxate&oldid=1301320738"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp