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Fezakinumab

From Wikipedia, the free encyclopedia
Monoclonal antibody
Pharmaceutical compound
Fezakinumab
Monoclonal antibody
TypeWhole antibody
TargetIL-22
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6408H9873N1706O2016S44
Molar mass144479.04 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Fezakinumab is a human monoclonal antibody againstinterleukin-22,[1] designed for the treatment ofpsoriasis andrheumatoid arthritis.[2]

Research and development

[edit]

Wyeth discovered and initially developed the drug, and clinical development continued after that company was acquired byPfizer. Fezakinumab, in combination withmethotrexate, completed a phase II trial in rheumatoid arthritis,[3] but data were not released. A small phase II trial of fezakinumab showed significant improvement in theScoring Atopic Dermatitis (SCORAD) score for patients with severeatopic dermatitis.[4]

References

[edit]
  1. ^"Statement On A Nonproprietary Name Adopted By The USAN Council: Fezakinumab"(PDF).American Medical Association. Retrieved2017-06-07.
  2. ^"Pfizer Pipeline"(PDF). 28 February 2011. Archived fromthe original(PDF) on 2011-09-04. Retrieved2012-09-25.
  3. ^"Emerging Parenteral Biologic Therapies for Rheumatoid Arthritis".Living Medical eTextbook - Rheumatology - Projects In Knowledge. p. 4. Archived fromthe original on 24 January 2018. Retrieved2017-06-07.
  4. ^Richardson B."Atopic dermatitis: fezakinumab shows benefit in severe disease".quantiamd.univadis.com. Aptus Health. Archived fromthe original on 25 January 2018. Retrieved24 January 2018.
Immune system
Human
Mouse
Chimeric
Humanized
Chimeric + humanized
Interleukin
Human
Humanized
Veterinary
Inflammatorylesions
Mouse
IL-1
IL-2
IL-3
IL-4
IL-5
IL-6
IL-7
IL-8
  • See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)here instead.
IL-9
IL-10
IL-11
IL-12
IL-13
IL-15
IL-17
IL-18
IL-20
IL-21
IL-22
IL-23
IL-27
IL-28
IL-31
IL1RL1
IL1RL2
Others
JAK
Others
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