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Fenticlor

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Fenticlor
Clinical data
Routes of
administration
topical
Identifiers
  • Bis[2-hydroxy-5-chlorophenyl] sulfide
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.002.336Edit this at Wikidata
Chemical and physical data
FormulaC12H8Cl2O2S
Molar mass287.15 g·mol−1
Melting point174 °C (345 °F)

Fenticlor (also spelled fentichlor) is anantibacterial andantifungal agent for topical use. It is an antimicrobial agent. It is also used in veterinary medicine.

Synthesis

[edit]

It is prepared by the AlCl3-catalyzed reaction of4-chlorophenol withsulfur dichloride.[1] It can also be prepared by chlorination of bis[2-hydroxyphenyl]sulfide.[2][3]

Safety

[edit]

TheLD50 (rats, oral) of fenticlor is 3250 mg/kg.[1] It may causephotosensitivity.[4]

References

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  1. ^abFiege H, Voges HW, Hamamoto T, Umemura S, Iwata T, Miki H, Fujita Y, Buysch HJ, Garbe D, Paulus W (2007). "Phenol Derivatives".Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH.doi:10.1002/14356007.a19_313.ISBN 978-3-527-30673-2.
  2. ^DE 568944, Muth F, "Verfahren zur Darstellung von Bis-(halogen-oxyaryl)-sulfiden", issued 1931, assigned toI. G. Farben 
  3. ^Dunning F, Dunning B, Drake WE (1931). "Preparation and Bacteriological Study of Some Symmetrical Organic Sulfides".Journal of the American Chemical Society.53 (9):3466–3469.Bibcode:1931JAChS..53.3466D.doi:10.1021/ja01360a035.
  4. ^Burry JN (June 1974)."Letter: Fenticlor, actinic reticuloid, and antihistamines".British Medical Journal.2 (5918):556–7.doi:10.1136/bmj.2.5918.556-c.PMC 1610938.PMID 4152080.
Acridine derivatives
Biguanides andamidines
Phenol and derivatives
Nitrofuran derivatives
Iodine products
Quinoline derivatives
Quaternary ammonium compounds
Mercurial products
Silver compounds
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