Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Fenoverine

From Wikipedia, the free encyclopedia
Chemical compound
icon
This articleneeds additional citations forverification. Please helpimprove this article byadding citations to reliable sources. Unsourced material may be challenged and removed.
Find sources: "Fenoverine" – news ·newspapers ·books ·scholar ·JSTOR
(May 2021) (Learn how and when to remove this message)
icon
You can helpexpand this article with text translated fromthe corresponding article in Italian. (May 2014)Click [show] for important translation instructions.
  • Machine translation, likeDeepL orGoogle Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia.
  • Consideradding a topic to this template: there are already 259 articles in themain category, and specifying|topic= will aid in categorization.
  • Do not translate text that appears unreliable or low-quality. If possible, verify the text with references provided in the foreign-language article.
  • Youmust providecopyright attribution in theedit summary accompanying your translation by providing aninterlanguage link to the source of your translation. A model attribution edit summary isContent in this edit is translated from the existing Italian Wikipedia article at [[:it:Fenoverina]]; see its history for attribution.
  • You may also add the template{{Translated|it|Fenoverina}} to thetalk page.
  • For more guidance, seeWikipedia:Translation.
Pharmaceutical compound
Fenoverine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 2-[4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl]-1-(10H-phenothiazin-10-yl)ethanone
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.048.666Edit this at Wikidata
Chemical and physical data
FormulaC26H15N3O3S
Molar mass449.48 g·mol−1
3D model (JSmol)
  • C1CN(CCN1CC2=CC3=C(C=C2)OCO3)CC(=O)N4C5=CC=CC=C5SC6=CC=CC=C64
  • InChI=1S/C26H25N3O3S/c30-26(29-20-5-1-3-7-24(20)33-25-8-4-2-6-21(25)29)17-28-13-11-27(12-14-28)16-19-9-10-22-23(15-19)32-18-31-22/h1-10,15H,11-14,16-18H2
  • Key:UBAJTZKNDCEGKL-UHFFFAOYSA-N
  (verify)

Fenoverine (INN) is anantispasmodic [also known as spasmolytics] drug,[1] which acts by inhibiting calcium channels[2] [much in the same way as traditional calcium channel blockers, which are used as antianginal drugs]. In the case of Fenoverine, the relaxation occurs in abdominal / intestinal smooth muscles, while in case of antianginal drugs, the relaxation occurs in coronary vessels. NotablyFenoverine does not act as an antianginal agent.

Toxicity

[edit]

Fenoverine is known to causerhabdomyolysis.[2][3]

References

[edit]
  1. ^Martínez-Vázquez MA, Vázquez-Elizondo G, González-González JA, Gutiérrez-Udave R, Maldonado-Garza HJ, Bosques-Padilla FJ (2012)."Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis".Revista de Gastroenterologia de Mexico.77 (2):82–90.doi:10.1016/j.rgmx.2012.04.002.PMID 22672854.
  2. ^abChariot P, Ratiney R, Le Maguet F, Fourestié V, Astier A, Gherardi R (August 1995). "Fenoverine-induced rhabdomyolysis".Hum Exp Toxicol.14 (8):654–656.Bibcode:1995HETox..14..654C.doi:10.1177/096032719501400805.PMID 7576832.
  3. ^Cho J, Na J, Bae E, Lee TW, Jang HN, Cho HS, Chang SH, Park DJ (April 2020)."The incidence, risk factors, and clinical outcomes of rhabdomyolysis associated with fenoverine prescription: a retrospective study in South Korea (1999-2014)".BMC Pharmacol Toxicol.21 (1) 30.doi:10.1186/s40360-020-00408-3.PMC 7183697.PMID 32334639.
Drugs for
functional
bowel
disorders
Antimuscarinics
Tertiary
amino group
Quaternary
ammonium

compounds
Phosphodiesterase
inhibitors
Acting on
serotonin receptors
Other
Belladonna
and derivatives
(antimuscarinics)
Propulsives


Stub icon

Thisdrug article relating to thegastrointestinal system is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Fenoverine&oldid=1318142832"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp