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Fallypride

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Chemical compound

Pharmaceutical compound

Fallypride (¹⁸F)
Clinical data

Pregnancy category	N/A
ATC code	none
Legal status
Legal status	Research compound
Identifiers
IUPAC name 5-(3-¹⁸F-fluoropropyl)-2,3-dimethoxy-N-[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide
CAS Number	166173-78-0
PubChemCID	10021692
DrugBank	DB15167
ChemSpider	8197265
UNII	G9FWZ369GX
ChEMBL	ChEMBL392158
CompTox Dashboard(EPA)	DTXSID30937173
Chemical and physical data
Formula	C₂₀H₂₉FN₂O₃
Molar mass	364.461 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC1=CC(=CC(=C1OC)C(=O)NC[C@@H]2CCCN2CC=C)CCCF
InChI InChI=1S/C20H29FN2O3/c1-4-10-23-11-6-8-16(23)14-22-20(24)17-12-15(7-5-9-21)13-18(25-2)19(17)26-3/h4,12-13,16H,1,5-11,14H2,2-3H3,(H,22,24)/t16-/m0/s1 Key:OABRYNHZQBZDMG-INIZCTEOSA-N

Fallypride is a high-affinity dopamine D2/D3receptor antagonist used in medical research,^[1] usually in the form offallypride (¹⁸F) as apositron emission tomography (PET)radiotracer in human studies.^[2]^[3]

^Mukherjee J, Yang ZY, Das MK, Brown T (April 1995). "Fluorinated benzamide neuroleptics – III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer".Nuclear Medicine and Biology.22 (3):283–96.doi:10.1016/0969-8051(94)00117-3.PMID 7627142.
^Mukherjee J, Christian BT, Dunigan KA, Shi B, Narayanan TK, Satter M, Mantil J (December 2002). "Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors".Synapse.46 (3):170–88.doi:10.1002/syn.10128.PMID 12325044.S2CID 24852944.
^Rieck RW, Ansari MS, Whetsell WO, Deutch AY, Kessler RM (February 2004)."Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies".Neuropsychopharmacology.29 (2):362–72.doi:10.1038/sj.npp.1300336.PMID 14627996.

Agonists	Benzazepines:6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam Zelandopam Ergolines:Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride Dihydrexidine derivatives:A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines:BCO-001 Deoxyepinephrine (N-methyldopamine, epinine) Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Melevodopa L-Phenylalanine L-Tyrosine XP21279 Others:A-68930 Apomorphine Isocorypalmine Nuciferine PF-6649751 PF 6669571 Propylnorapomorphine Rotigotine SKF-89,145 SKF-89,626 Stepholidine Tavapadon Tetrahydropalmatine
PAMs	Tetrahydroisoquinolines:DETQ DPTQ Mevidalen
Antagonists	Typical antipsychotics:Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol Atypical antipsychotics:Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine Others:Berupipam Ecopipam EEDQ Metitepine (methiothepin) Odapipam Perlapine SCH-23390