This intronless gene is a member of thefrizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2".Int J Oncol.18 (5):991–6.doi:10.3892/ijo.18.5.991.PMID11295046.
Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled".Biochem. Biophys. Res. Commun.286 (4):771–778.doi:10.1006/bbrc.2001.5430.PMID11520064.
Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)".Ophthalmic Genet.25 (2):81–90.doi:10.1080/13816810490514270.PMID15370539.S2CID32817238.
"Frizzled Receptors: FZD8".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2014-09-03. Retrieved2008-12-04.
Overview of all the structural information available in thePDB forUniProt:Q9H461 (Human Frizzled-8 (FZD8)) at thePDBe-KB.
