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Frizzled-5

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(Redirected fromFZD5)

Protein-coding gene in the species Homo sapiens

FZD5

Identifiers

Aliases

FZD5, C2orf31, HFZ5, frizzled class receptor 5

External IDs

OMIM:601723;MGI:108571;HomoloGene:2590;GeneCards:FZD5;OMA:FZD5 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q33.3	Start	207,762,598bp^[1]
Band	2q33.3	End	207,769,906bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1 C2\|1 32.74 cM	Start	64,769,717bp^[2]
Band	1 C2\|1 32.74 cM	End	64,776,910bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

jejunal mucosa

mucosa of sigmoid colon

lower lobe of lung

mucosa of ileum

duodenum

mucosa of transverse colon

palpebral conjunctiva

kidney tubule

visceral pleura

tibia

Top expressed in

median eminence

hair follicle

epithelium of small intestine

epithelium of stomach

ciliary body

left colon

arcuate nucleus

Paneth cell

calvaria

ileum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	amyloid-beta binding signal transducer activity Wnt-protein binding protein binding protein kinase binding ubiquitin protein ligase binding transmembrane signaling receptor activity Wnt-activated receptor activity G protein-coupled receptor activity
Cellular component	clathrin-coated endocytic vesicle membrane Golgi apparatus early endosome membrane membrane bicellular tight junction Golgi membrane plasma membrane cell surface early endosome perinuclear region of cytoplasm integral component of membrane
Biological process	G protein-coupled receptor signaling pathway T cell differentiation in thymus chorionic trophoblast cell differentiation positive regulation of protein targeting to mitochondrion positive regulation of JUN kinase activity apoptotic process involved in morphogenesis regulation of chorionic trophoblast cell proliferation regulation of bicellular tight junction assembly regulation of canonical Wnt signaling pathway cellular response to molecule of bacterial origin positive regulation of interferon-gamma production embryonic axis specification labyrinthine layer blood vessel development cell maturation Wnt signaling pathway embryonic camera-type eye development multicellular organism development cell surface receptor signaling pathway vasculature development regulation of autophagy of mitochondrion branching involved in labyrinthine layer morphogenesis embryonic camera-type eye morphogenesis post-embryonic camera-type eye development positive regulation of T cell cytokine production angiogenesis neuron differentiation Wnt signaling pathway involved in dorsal/ventral axis specification canonical Wnt signaling pathway synapse assembly syncytiotrophoblast cell differentiation involved in labyrinthine layer development anterior/posterior axis specification, embryo Spemann organizer formation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation signal transduction Wnt signaling pathway, calcium modulating pathway Wnt signaling pathway, planar cell polarity pathway beta-catenin destruction complex disassembly
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


7855


14367

Ensembl


ENSG00000163251


ENSMUSG00000045005

UniProt


Q13467


Q9EQD0

RefSeq (mRNA)


NM_030804 NM_003468


NM_001033193 NM_001042659 NM_022721

RefSeq (protein)


NP_003459


NP_001036124 NP_073558

Location (UCSC)

Chr 2: 207.76 – 207.77 Mb

Chr 1: 64.77 – 64.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Frizzled-5(Fz-5) is aprotein that in humans is encoded by theFZD5gene.^[5]^[6]^[7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Fz-5 is believed to be the receptor for the Wnt5A ligand.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000163251 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000045005 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996)."A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled".J Biol Chem.271 (8):4468–76.doi:10.1074/jbc.271.8.4468.PMID 8626800.
^Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region".Int J Oncol.19 (1):105–10.doi:10.3892/ijo.19.1.105.PMID 11408929.
^^a ^b"Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)".

External links

[edit]

"Frizzled Receptors: FZD₅".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-06-25. Retrieved2008-12-04.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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