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Frizzled-4

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From Wikipedia, the free encyclopedia

(Redirected fromFZD4)

Protein-coding gene in the species Homo sapiens

FZD4

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
5BPB,5BPQ,5BQC,5BQE,5CL1,5CM4

Identifiers

Aliases

FZD4, CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4, frizzled class receptor 4

External IDs

OMIM:604579;MGI:108520;HomoloGene:7325;GeneCards:FZD4;OMA:FZD4 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q14.2	Start	86,945,679bp^[1]
Band	11q14.2	End	86,955,395bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7 D3\|7 49.32 cM	Start	89,053,563bp^[2]
Band	7 D3\|7 49.32 cM	End	89,062,342bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

adipose tissue

subcutaneous adipose tissue

right lung

abdominal fat

parietal pleura

synovial joint

tendon of biceps brachii

pericardium

seminal vesicula

thoracic diaphragm

Top expressed in

retinal pigment epithelium

choroid plexus of fourth ventricle

ciliary body

internal carotid artery

Epithelium of choroid plexus

epithelium of stomach

ankle

subcutaneous adipose tissue

white adipose tissue

external carotid artery

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	PDZ domain binding protein homodimerization activity signal transducer activity protein binding protein heterodimerization activity Wnt-activated receptor activity ubiquitin protein ligase binding transmembrane signaling receptor activity cytokine binding G protein-coupled receptor activity Wnt-protein binding amyloid-beta binding signaling receptor activity protein-containing complex binding
Cellular component	clathrin-coated endocytic vesicle membrane membrane cell-cell junction plasma membrane integral component of plasma membrane cell surface extracellular exosome integral component of membrane clathrin-coated vesicle membrane dendrite synapse glutamatergic synapse
Biological process	negative regulation of cell-substrate adhesion cellular response to retinoic acid G protein-coupled receptor signaling pathway luteinization extracellular matrix-cell signaling positive regulation of JUN kinase activity positive regulation of DNA-binding transcription factor activity hearing Wnt signaling pathway regulation of vascular endothelial growth factor receptor signaling pathway vasculogenesis positive regulation of transcription, DNA-templated multicellular organism development cerebellum vasculature morphogenesis cell surface receptor signaling pathway progesterone secretion blood vessel development neuron differentiation retinal blood vessel morphogenesis canonical Wnt signaling pathway substrate adhesion-dependent cell spreading locomotion involved in locomotory behavior retina vasculature morphogenesis in camera-type eye signal transduction Wnt signaling pathway, calcium modulating pathway Wnt signaling pathway, planar cell polarity pathway membrane organization non-canonical Wnt signaling pathway positive regulation of neuron projection arborization cellular response to leukemia inhibitory factor
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


8322


14366

Ensembl


ENSG00000174804


ENSMUSG00000049791

UniProt


Q9ULV1


Q61088

RefSeq (mRNA)


NM_012193


NM_008055

RefSeq (protein)


NP_036325


NP_032081

Location (UCSC)

Chr 11: 86.95 – 86.96 Mb

Chr 7: 89.05 – 89.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Frizzled-4(Fz-4) is aprotein that in humans is encoded by theFZD4gene.^[5]^[6]^[7] Fz-4 has also been designated asCD344 (cluster of differentiation 344).

Function

[edit]

This gene is a member of thefrizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Frizzled-4 is the only representative of frizzled family members that binds strongly an additional ligandNorrin that is functionally similar but structurally different from Wingless type proteins.^[8] FZD4 signaling induced by Norrin regulates vascular development of vertebrateretina and controls important blood vessels in the ear. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorterisoform has been described, however, its expression is not supported by other experimental evidence.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000174804 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000049791 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kirikoshi H, Sagara N, Koike J, Tanaka K, Sekihara H, Hirai M, Katoh M (Nov 1999). "Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21".Biochemical and Biophysical Research Communications.264 (3):955–61.Bibcode:1999BBRC..264..955K.doi:10.1006/bbrc.1999.1612.PMID 10544037.
^Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF (Apr 2004)."Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q".American Journal of Human Genetics.74 (4):721–30.doi:10.1086/383202.PMC 1181948.PMID 15024691.
^^a ^b"Entrez Gene: FZD4 frizzled homolog 4 (Drosophila)".
^Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J (March 2004)."Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair".Cell.116 (6):883–895.doi:10.1016/S0092-8674(04)00216-8.PMID 15035989.S2CID 18687651.

External links

[edit]

"Frizzled Receptors: FZD₄".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-04.]
GeneReviews/NCBI/NIH/UW entry on Familial Exudative Vitreoretinopathy, Autosomal Dominant

Thistransmembrane receptor-related article is astub. You can help Wikipedia byexpanding it.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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Frizzled-4

Function

See also

References

Further reading

External links