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FUB-PB-22

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
FUB-PB-22
Legal status
Legal status
Identifiers
  • quinolin-8-yl 1-[(4-fluorophenyl)methyl]-1H-indole-3-carboxylate
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC25H17FN2O2
Molar mass396.421 g·mol−1
3D model (JSmol)
  • Fc1ccc(cc1)Cn1cc(c2c1cccc2)C(=O)Oc1cccc2c1nccc2
  • InChI=1S/C25H17FN2O2/c26-19-12-10-17(11-13-19)15-28-16-21(20-7-1-2-8-22(20)28)25(29)30-23-9-3-5-18-6-4-14-27-24(18)23/h1-14,16H,15H2
  • Key:ROHVURVXAOMRJY-UHFFFAOYSA-N

FUB-PB-22 (QUFUBIC) is anindole-basedsynthetic cannabinoid that is a potentagonist of theCB1 receptor and has been sold online as adesigner drug.[1][2]

Pharmacology

[edit]

FUB-PB-22 acts as afull agonist with abinding affinity of 0.386nM atCB1 and 0.478nM atCB2cannabinoid receptors.[3]

Legal status

[edit]

FUB-PB-22 is anAnlage II controlled substance in Germany. It was scheduled in Japan in July 2014.

As of October 2015 FUB-PB-22 is a controlled substance in China.[4]

It is also banned in Sweden.[5]

See also

[edit]

References

[edit]
  1. ^"FUB-PB-22". Southern Association of Forensic Scientists. Archived fromthe original on 27 May 2015. Retrieved23 July 2015.
  2. ^Uchiyama N, Shimokawa Y, Kikura-Hanajiri R, Demizu Y, Goda Y, Hakamatsuka T (February 2015)."N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products".Forensic Toxicology.33 (2):244–259.doi:10.1007/s11419-015-0268-7.PMC 4525202.PMID 26257833.
  3. ^Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE (1 July 2016)."Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice".Forensic Toxicology.34 (2):329–343.doi:10.1007/s11419-016-0320-2.PMC 4929166.PMID 27429655.
  4. ^"关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived fromthe original on 1 October 2015. Retrieved1 October 2015.
  5. ^"Cannabinoider föreslås bli klassificerade som hälsofarlig vara". Folkhälsomyndigheten. 28 May 2014. Retrieved23 July 2015.
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