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| Formula | C25H26FN3O |
| Molar mass | 403.501 g·mol−1 |
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FUB-APINACA (also known asA-FUBINACA according to the EMCCDA framework for naming synthetic cannabinoids[1] andFUB-AKB48) is anindazole-basedsynthetic cannabinoid that is presumed to be a potentagonist of theCB1 receptor and has been sold online as adesigner drug.[2] It is an analog ofAPINACA and5F-APINACA where the pentyl chain has been replaced with fluorobenzyl.
FUB-APINACA acts as afull agonist with abinding affinity of 1.06 nM atCB1 and 0.174 nM atCB2cannabinoid receptors.[3]
In the United States, FUB-APINACA was temporarily emergency scheduled by the DEA in 2019.[4] and made a permanentSchedule I Controlled Substance nationwide on April 7, 2022.[5] Previously, it was illegal only inAlabama (listed as FUB-AKB48).[6]
Sweden's public health agency suggested classifying FUB-APINACA as a hazardous substance on November 10, 2014.[7]
