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FRMPD4

From Wikipedia, the free encyclopedia
Protein-coding gene in humans
FRMPD4
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

4WND,4WNE,4WNF,4WNG

Identifiers
AliasesFRMPD4, PDZD10, PDZK10, FERM and PDZ domain containing 4, MRX104
External IDsOMIM:300838;MGI:3042378;HomoloGene:45843;GeneCards:FRMPD4;OMA:FRMPD4 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for FRMPD4
Genomic location for FRMPD4
BandXp22.2Start12,138,466bp[1]
End12,724,523bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for FRMPD4
Genomic location for FRMPD4
BandX|X F5Start166,254,305bp[2]
End167,360,227bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • endothelial cell

  • Brodmann area 23

  • Brodmann area 46

  • orbitofrontal cortex

  • superior frontal gyrus

  • postcentral gyrus

  • primary visual cortex

  • entorhinal cortex

  • prefrontal cortex
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • hippocampus proper

  • primary visual cortex

  • superior frontal gyrus

  • Cerebellum

  • cerebellar cortex

  • striatum of neuraxis

  • vasculature

  • vasculature of organ

  • olfactory bulb
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9758

333605

Ensembl

ENSG00000169933

ENSMUSG00000049176

UniProt

Q14CM0

A2AFR3

RefSeq (mRNA)

NM_014728

NM_001033330
NM_001290427
NM_001290428
NM_001359072
NM_001368936

NM_001369234

RefSeq (protein)
NP_055543
NP_001355324
NP_001355325
NP_001355326
NP_001355327

NP_001355328
NP_001355329
NP_001355330
NP_001355331

NP_001028502
NP_001277356
NP_001277357
NP_001346001
NP_001355865

NP_001356163

Location (UCSC)Chr X: 12.14 – 12.72 MbChr X: 166.25 – 167.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FERM and PDZ domain containing 4 is aprotein that in humans is encoded by the FRMPD4gene.[5]

Function

[edit]

This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such asPSD-95), it functions as a positive regulator ofdendritic spinemorphogenesis and density, and is required for the maintenance ofexcitatory synaptic transmission.

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000169933Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000049176Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: FERM and PDZ domain containing 4". Retrieved2016-10-01.

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.


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