Human protein-coding gene
Forkhead box protein P4 is aprotein that in humans is encoded by theFOXP4 gene .[ 5]
This gene belongs to subfamily P of theforkhead box (FOX)transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specificgene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalianoncogenesis . This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding differentisoforms .[ 5] Long COVID as such, increasing the chances of developing the little-understood syndrome 1.6 fold, a finding which has major implications forCOVID-19 pandemic research.[ 6] [ 7]
Katoh M, Katoh M (2005). "Human FOX gene family (Review)".Int. J. Oncol .25 (5):1495– 500.doi :10.3892/ijo.25.5.1495 .PMID 15492844 . Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" .Proc. Natl. Acad. Sci. U.S.A .99 (26):16899– 903.Bibcode :2002PNAS...9916899M .doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Lu MM, Li S, Yang H, Morrisey EE (2003)."Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues" .Gene Expr. Patterns .2 (3– 4):223– 8.doi :10.1016/S1567-133X(02)00058-3 PMID 12617805 . (Retracted, seedoi :10.1016/S0925-4773(03)00085-6 ) Teufel A, Wong EA, Mukhopadhyay M, Malik N, Westphal H (2003)."FoxP4, a novel forkhead transcription factor" .Biochim. Biophys. Acta .1627 (2– 3):147– 52.doi :10.1016/S0167-4781(03)00074-5 .PMID 12818433 . Lu MM, Li S, Yang H, Morrisey EE (2002)."Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues" .Mech. Dev .119 (Suppl 1): S197–202.doi :10.1016/S0925-4773(03)00116-3 PMID 14516685 .S2CID 935988 . Li S, Weidenfeld J, Morrisey EE (2004)."Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions" .Mol. Cell. Biol .24 (2):809– 22.doi :10.1128/MCB.24.2.809-822.2004 .PMC 343786 PMID 14701752 . Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs" .Nat. Genet .36 (1):40– 5.doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" .Genome Res .14 (10B):2121– 7.doi :10.1101/gr.2596504 .PMC 528928 PMID 15489334 . Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP (2006)."Transcriptional genomics associates FOX transcription factors with human heart failure" .Circulation .114 (12):1269– 76.doi :10.1161/CIRCULATIONAHA.106.632430 PMID 16952980 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
