Forkhead box protein G1 is aprotein that in humans is encoded by theFOXG1gene.[5][6][7]
This gene belongs to theforkhead family of transcription factors that is characterized by a distinct forkhead domain. The complete function of this gene has not yet been determined; however, it has been shown to play a role in the development of thebrain andtelencephalon. Mutations of FOXG1 are the cause of FoxG1 syndrome.[8]
FOXG1 syndrome is characterized by microcephaly and brain malformations. It affects most aspects of development and can cause seizures. FOXG1 syndrome is classified as anautism spectrum disorder and was previously considered a variant ofRett syndrome.[9][10]
FOXG1 has been shown tointeract withJARID1B.[11]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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