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FHL3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

FHL3
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1WYH,2CUQ,2EHE

Identifiers
AliasesFHL3, SLIM2, four and a half LIM domains 3
External IDsOMIM:602790;MGI:1341092;HomoloGene:37928;GeneCards:FHL3;OMA:FHL3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for FHL3
Genomic location for FHL3
Band1p34.3Start37,996,770bp[1]
End38,005,606bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for FHL3
Genomic location for FHL3
Band4|4 D2.2Start124,594,494bp[2]
End124,602,404bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • gastrocnemius muscle

  • Skeletal muscle tissue of rectus abdominis

  • vastus lateralis muscle

  • Skeletal muscle tissue of biceps brachii

  • thoracic diaphragm

  • triceps brachii muscle

  • deltoid muscle

  • tibialis anterior muscle

  • body of uterus
Top expressed in
  • muscle of thigh

  • lip

  • granulocyte

  • esophagus

  • genital tubercle

  • yolk sac

  • urethra

  • skeletal muscle tissue

  • embryo

  • male urethra
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2275

14201

Ensembl

ENSG00000183386

ENSMUSG00000032643

UniProt

Q13643
Q96C98

Q9R059

RefSeq (mRNA)

NM_004468
NM_001243878

NM_010213

RefSeq (protein)

NP_001230807
NP_004459
NP_001230807.1

NP_034343

Location (UCSC)Chr 1: 38 – 38.01 MbChr 4: 124.59 – 124.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Four and a half LIM domains protein 3 is aprotein that in humans is encoded by theFHL3gene.[5][6][7]

LIM proteins are defined by the possession of a highly conserved doublezinc finger motif called theLIM domain.[7]

Function

[edit]

FHL3 plays a role in myogenesis,[8] and also stimulates the development of neural crest by enhancingBMP signaling.[9]

Interactions

[edit]

FHL3 has been shown tointeract with:

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000183386Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000032643Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle".Biochem Biophys Res Commun.225 (2):632–8.Bibcode:1996BBRC..225..632M.doi:10.1006/bbrc.1996.1222.PMID 8753811.
  6. ^Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1".Somat Cell Mol Genet.24 (3):197–202.doi:10.1023/B:SCAM.0000007122.03392.4b.PMID 10226657.S2CID 40511123.
  7. ^ab"Entrez Gene: FHL3 four and a half LIM domains 3".
  8. ^Cottle et al., J Cell Sci. 2007 Apr 15;120(Pt 8):1423-35. doi: 10.1242/jcs.004739
  9. ^Intracellular enhancement of BMP signaling by LIM-domain protein FHL3 controls spatiotemporal emergence of the neural crest driven by WNT signalingMansour Alkobtawi, Patrick Pla, Anne H. Monsoro-BurqbioRxiv 711192; doi:https://doi.org/10.1101/711192
  10. ^abFimia GM, De Cesare D, Sassone-Corsi P (November 2000)."A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM".Mol. Cell. Biol.20 (22):8613–22.doi:10.1128/mcb.20.22.8613-8622.2000.PMC 102166.PMID 11046156.
  11. ^abTurner J, Nicholas H, Bishop D, Matthews JM, Crossley M (April 2003)."The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2".J. Biol. Chem.278 (15):12786–95.doi:10.1074/jbc.M300587200.PMID 12556451.
  12. ^Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM (2001). "Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)".J. Cell. Biochem.80 (3):293–303.doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U.PMID 11135358.S2CID 36346381.
  13. ^Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V (July 2004)."The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor".J. Biol. Chem.279 (27):28641–52.doi:10.1074/jbc.M312894200.PMID 15117962.

Further reading

[edit]

External links

[edit]
PDB gallery
  • 1wyh: Solution structure of the LIM domain from human Skeletal muscle LIM-protein 2
    1wyh: Solution structure of the LIM domain from human Skeletal muscle LIM-protein 2
  • 2cuq: Solution Structure of Second Lim Domain from Human Skeletal Muscle Lim-Protein 2
    2cuq: Solution Structure of Second Lim Domain from Human Skeletal Muscle Lim-Protein 2
(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.


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