This gene is a member of the Src family of proteintyrosine kinases (PTKs). The encoded protein containsN-terminal sites formyristoylation andpalmitoylation, a PTK domain, andSH2 andSH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cellmigration andadhesion triggered by the beta-2integrin signal transduction pathway. Infection withEpstein–Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.[6]
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