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FGF22

From Wikipedia, the free encyclopedia
Protein
fibroblast growth factor 22
Identifiers
SymbolFGF22
NCBI gene27006
HGNC3679
OMIM605831
RefSeqNM_020637
UniProtQ9HCT0
Other data
LocusChr. 19p13.3
Search for
StructuresSwiss-model
DomainsInterPro

Fibroblast growth factor 22 is aprotein which in humans is encoded by theFGF22gene.[1][2]

Function

[edit]

The protein encoded by this gene is a member of thefibroblast growth factor (FGF) family. FGF family members possess broadmitogenic and cell survival activities, and are involved in a variety of biological processes, includingembryonic development, cell growth,morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development.[3]

References

[edit]
  1. ^Umemori H, Linhoff MW, Ornitz DM, Sanes JR (July 2004)."FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain".Cell.118 (2):257–70.doi:10.1016/j.cell.2004.06.025.PMID 15260994.S2CID 18836066.
  2. ^Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM (June 2006)."Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family".The Journal of Biological Chemistry.281 (23):15694–700.doi:10.1074/jbc.M601252200.PMC 2080618.PMID 16597617.
  3. ^"Entrez Gene: Fibroblast growth factor 22".


This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Fibroblast
FGF receptor ligands:
KGF
FGF homologous factors:
hormone-like:FGF15/19
EGF-like domain
TGFβ pathway
Insulin/IGF/
Relaxin family
Insulin andInsulin-like growth factor
Relaxin family peptide hormones
Platelet-derived
Vascular endothelial
Other
Angiopoietin
CNTF
EGF (ErbB)
EGF
(ErbB1/HER1)
ErbB2/HER2
ErbB3/HER3
ErbB4/HER4
FGF
FGFR1
FGFR2
FGFR3
FGFR4
Unsorted
HGF (c-Met)
IGF
IGF-1
IGF-2
Others
LNGF (p75NTR)
PDGF
RET (GFL)
GFRα1
GFRα2
GFRα3
GFRα4
Unsorted
SCF (c-Kit)
TGFβ
Trk
TrkA
TrkB
TrkC
VEGF
Others


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