Fibulin-1 has modular domain structure and includes a series of nineepidermal growth factor-like modules followed by afibulin-type module, a module found in all members of the fibulin gene family.[6]
The human fibulin-1 gene, FBLN1, encodes foursplice variants designated fibulin-1A, B, C and D, which differ in theircarboxy terminal regions. In mouse, chicken and the nematode,C. elegans, only two fibulin-1 variants are produced, fibulin-1C and fibulin-1D.[5]
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^Adam S, Göhring W, Wiedemann H, Chu ML, Timpl R, Kostka G (Sep 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules".Journal of Molecular Biology.272 (2):226–36.doi:10.1006/jmbi.1997.1244.PMID9299350.
Argraves WS, Dickerson K, Burgess WH, Ruoslahti E (Aug 1989). "Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain".Cell.58 (4):623–9.doi:10.1016/0092-8674(89)90097-4.PMID2527614.S2CID24834825.
Sasaki T, Göhring W, Pan TC, Chu ML, Timpl R (Dec 1995). "Binding of mouse and human fibulin-2 to extracellular matrix ligands".Journal of Molecular Biology.254 (5):892–9.doi:10.1006/jmbi.1995.0664.PMID7500359.
Mattei MG, Pan TC, Zhang RZ, Timpl R, Chu ML (Jul 1994). "The fibulin-1 gene (FBLN1) is located on human chromosome 22 and on mouse chromosome 15".Genomics.22 (2):437–8.doi:10.1006/geno.1994.1406.PMID7806231.
Korenberg JR, Chen XN, Tran H, Argraves WS (1995). "Localization of the human gene for fibulin-1 (FBLN1) to chromosome band 22q13.3".Cytogenetics and Cell Genetics.68 (3–4):192–3.doi:10.1159/000133911.PMID7842734.
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Miosge N, Götz W, Sasaki T, Chu ML, Timpl R, Herken R (Feb 1996). "The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo".The Histochemical Journal.28 (2):109–16.doi:10.1007/BF02331415.PMID8737292.S2CID25996538.
Tran H, Mattei M, Godyna S, Argraves WS (Mar 1997). "Human fibulin-1D: molecular cloning, expression and similarity with S1-5 protein, a new member of the fibulin gene family".Matrix Biology.15 (7):479–93.doi:10.1016/S0945-053X(97)90021-4.PMID9106159.
Adam S, Göhring W, Wiedemann H, Chu ML, Timpl R, Kostka G (Sep 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules".Journal of Molecular Biology.272 (2):226–36.doi:10.1006/jmbi.1997.1244.PMID9299350.
