This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated inpsoriasis tissue.Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.[6]
Thephytocannabinoids (THC andCBD) inhibitendocannabinoidanandamide (AEA) uptake by targeting FABP5, and competition forFABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids.[7] Results show that cannabinoids inhibitkeratinocyteproliferation, and therefore support a potential role for cannabinoids in the treatment of psoriasis.[8]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Madsen P, Rasmussen HH, Leffers H, Honoré B, Celis JE (September 1992). "Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins".The Journal of Investigative Dermatology.99 (3):299–305.doi:10.1111/1523-1747.ep12616641.PMID1512466.
^Hagens G, Roulin K, Hotz R, Saurat JH, Hellman U, Siegenthaler G (February 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales".Molecular and Cellular Biochemistry.192 (1–2):123–8.doi:10.1023/A:1006894909694.PMID10331666.S2CID24171894.
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes".Electrophoresis.13 (12):960–9.doi:10.1002/elps.11501301199.PMID1286667.S2CID41855774.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
Siegenthaler G, Hotz R, Chatellard-Gruaz D, Jaconi S, Saurat JH (January 1993). "Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP)".Biochemical and Biophysical Research Communications.190 (2):482–7.doi:10.1006/bbrc.1993.1073.PMID8427590.
Masouyé I, Saurat JH, Siegenthaler G (1996). "Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study".Dermatology.192 (3):208–13.doi:10.1159/000246367.PMID8726632.
Masouyé I, Hagens G, Van Kuppevelt TH, Madsen P, Saurat JH, Veerkamp JH, Pepper MS, Siegenthaler G (September 1997). "Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein".Circulation Research.81 (3):297–303.doi:10.1161/01.res.81.3.297.hdl:2066/25768.PMID9285630.S2CID21737640.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Watanabe R, Fujii H, Yamamoto A, Hashimoto T, Kameda K, Ito M, Ono T (November 1997). "Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin".Journal of Dermatological Science.16 (1):17–22.doi:10.1016/S0923-1811(97)00615-4.PMID9438903.
Hagens G, Roulin K, Hotz R, Saurat JH, Hellman U, Siegenthaler G (February 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales".Molecular and Cellular Biochemistry.192 (1–2):123–8.doi:10.1023/A:1006894909694.PMID10331666.S2CID24171894.
Hohoff C, Börchers T, Rüstow B, Spener F, van Tilbeurgh H (September 1999). "Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein".Biochemistry.38 (38):12229–39.doi:10.1021/bi990305u.PMID10493790.
O'Shaughnessy RF, Seery JP, Celis JE, Frischauf A, Watt FM (December 2000). "PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation".FEBS Letters.486 (2):149–54.Bibcode:2000FEBSL.486..149O.doi:10.1016/S0014-5793(00)02252-3.PMID11113456.S2CID23327194.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides".Nature Biotechnology.21 (5):566–9.doi:10.1038/nbt810.PMID12665801.S2CID23783563.
Ha MK, Chung KY, Lee JH, Bang D, Park YK, Lee KH (September 2004). "Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells".Experimental Dermatology.13 (9):543–50.doi:10.1111/j.0906-6705.2004.00196.x.PMID15335354.S2CID22923459.
