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F2RL2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

F2RL2

Identifiers

Aliases

F2RL2, PAR-3, PAR3, coagulation factor II thrombin receptor like 2

External IDs

OMIM:601919;MGI:1298208;HomoloGene:36151;GeneCards:F2RL2;OMA:F2RL2 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q13.3	Start	76,615,482bp^[1]
Band	5q13.3	End	76,623,413bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13 D1\|13 50.38 cM	Start	95,833,361bp^[2]
Band	13 D1\|13 50.38 cM	End	95,839,247bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

retinal pigment epithelium

skin of thigh

gallbladder

islet of Langerhans

testicle

skin of hip

gastric mucosa

smooth muscle tissue

nipple

Top expressed in

lumbar spinal ganglion

right lobe of liver

gastrula

blood

tibiofemoral joint

yolk sac

granulocyte

embryo

tail of embryo

submandibular gland

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	thrombin-activated receptor activity protein binding signal transducer activity phosphatidylinositol phospholipase C activity G protein-coupled receptor activity
Cellular component	integral component of membrane extracellular region plasma membrane integral component of plasma membrane apical plasma membrane membrane protein-containing complex
Biological process	platelet activation hemostasis thrombin-activated receptor signaling pathway blood coagulation response to wounding signal transduction positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2151


14064

Ensembl


ENSG00000164220


ENSMUSG00000021675

UniProt


O00254


O08675

RefSeq (mRNA)


NM_004101 NM_001256566


NM_010170

RefSeq (protein)


NP_001243495 NP_004092


NP_034300

Location (UCSC)

Chr 5: 76.62 – 76.62 Mb

Chr 13: 95.83 – 95.84 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Protease activated receptor 3 (PAR-3) also known ascoagulation factor II receptor-like 2 (F2RL2) andthrombin receptor-like 2, is aprotein that in humans is encoded by theF2RL2gene.

Function

[edit]

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of7-transmembrane receptors that couple toG proteins. F2RL2 is also a member of theprotease-activated receptor family and activated by thrombin. F2RL2 is activated byproteolytic cleavage of its extracellularamino terminus. The new amino terminus functions as a tetheredligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation bythrombin. It mediates thrombin-triggeredphosphoinositide hydrolysis and is expressed in a variety of tissues.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000164220 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000021675 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2".

Hollenberg MD, Compton SJ (2002). "International Union of Pharmacology. XXVIII. Proteinase-activated receptors".Pharmacol. Rev.54 (2):203–17.doi:10.1124/pr.54.2.203.PMID 12037136.S2CID 3188040.
Ishihara H, Connolly AJ, Zeng D, et al. (1997). "Protease-activated receptor 3 is a second thrombin receptor in humans".Nature.386 (6624):502–6.Bibcode:1997Natur.386..502I.doi:10.1038/386502a0.PMID 9087410.S2CID 4359291.
Schmidt VA, Nierman WC,Maglott DR, et al. (1998)."The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets".J. Biol. Chem.273 (24):15061–8.doi:10.1074/jbc.273.24.15061.PMID 9614115.
Xu WF, Andersen H, Whitmore TE, et al. (1998)."Cloning and characterization of human protease-activated receptor 4".Proc. Natl. Acad. Sci. U.S.A.95 (12):6642–6.Bibcode:1998PNAS...95.6642X.doi:10.1073/pnas.95.12.6642.PMC 22580.PMID 9618465.
Guyonnet Dupérat V, Jacquelin B, Boisseau P, et al. (1998). "Protease-activated receptor genes are clustered on 5q13".Blood.92 (1):25–31.doi:10.1182/blood.V92.1.25.413k41_25_31.PMID 9639495.
Kahn ML, Zheng YW, Huang W, et al. (1998). "A dual thrombin receptor system for platelet activation".Nature.394 (6694):690–4.Bibcode:1998Natur.394..690K.doi:10.1038/29325.PMID 9716134.S2CID 4408582.
Kahn ML, Hammes SR, Botka C, Coughlin SR (1998)."Gene and locus structure and chromosomal localization of the protease-activated receptor gene family".J. Biol. Chem.273 (36):23290–6.doi:10.1074/jbc.273.36.23290.PMID 9722561.
Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999)."Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin".J. Clin. Invest.103 (6):879–87.doi:10.1172/JCI6042.PMC 408153.PMID 10079109.
Hauck RW, Schulz C, Schömig A, et al. (1999). "alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors".Am. J. Physiol.277 (1 Pt 1): L22–9.doi:10.1152/ajplung.1999.277.1.L22.PMID 10409227.
Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). "PAR3 is a cofactor for PAR4 activation by thrombin".Nature.404 (6778):609–13.Bibcode:2000Natur.404..609N.doi:10.1038/35007085.PMID 10766244.S2CID 4410800.
O'Brien PJ, Prevost N, Molino M, et al. (2000)."Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1".J. Biol. Chem.275 (18):13502–9.doi:10.1074/jbc.275.18.13502.PMID 10788464.
Cumashi A, Ansuini H, Celli N, et al. (2001). "Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets".Thromb. Haemost.85 (3):533–8.doi:10.1055/s-0037-1615617.PMID 11307827.S2CID 37320447.
Sambrano GR, Weiss EJ, Zheng YW, et al. (2001). "Role of thrombin signalling in platelets in haemostasis and thrombosis".Nature.413 (6851):74–8.Bibcode:2001Natur.413...74S.doi:10.1038/35092573.PMID 11544528.S2CID 4327515.
Miike S, McWilliam AS, Kita H (2002)."Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2".J. Immunol.167 (11):6615–22.doi:10.4049/jimmunol.167.11.6615.PMID 11714832.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Even-Ram SC, Grisaru-Granovsky S, Pruss D, et al. (2003). "The pattern of expression of protease-activated receptors (PARs) during early trophoblast development".J. Pathol.200 (1):47–52.doi:10.1002/path.1338.PMID 12692840.S2CID 23097607.
Owen WG (2003). "PAR-3 is a low-affinity substrate, high affinity effector of thrombin".Biochem. Biophys. Res. Commun.305 (1):166–8.doi:10.1016/S0006-291X(03)00732-0.PMID 12732212.
Tanaka N, Morita T, Nezu A, et al. (2003). "Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1)".Life Sci.73 (3):301–10.doi:10.1016/S0024-3205(03)00269-8.PMID 12757837.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)