Junctional adhesion molecule A is aprotein that in humans is encoded by theF11Rgene.[5][6][7] It has also been designated asCD321 (cluster of differentiation 321).
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple transcript variants encoding two different isoforms have been found for this gene.[7]
F11 receptor has been shown tointeract withMLLT4,[8]CASK[8][9] andTight junction protein 1.[8][10]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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