| Eye transplantation | |
|---|---|
| Specialty | Ophthalmology,neurosurgery |
| Complications | Transplant rejection |
Eye transplantation is thetransplantation of theglobe of the human eye from a donor to a recipient.
Research efforts in whole eye transplantation (WET) are focused on its application in living human recipients, still some obstacles need to be addressed. Apart from the surgical and neurological considerations, there are key ethical concerns such as patients' perceptions and desires for both nonvision-restoring WET and vision-restoring WET, risks and benefits compared toprosthetic alternatives, psychosocial considerations for potential recipients regarding personal identity related to the donor's eyes, public perceptions of whole-eye donation, implications forcorneal transplantation eligibility of the donor's eyes, consent for whole-eye donation, and establishment of ethical mechanisms for allocation and distribution of WET. With limited studies available on this topic since the first vascularized composite allotransplantation (VCA)[1][2][3] took place in 1998, the understanding of WET is informed by a few studies with limitations. For example,amphibian regeneration cannot directly apply to humans. Ocular transplants may offer a viable option for restoring form in patients undergoing facial transplantation with enucleated orbits.[4]
In 1885 theRevue générale d'ophtalmologie reported that thestaphylomatous andbuphthalmic eye of a 17-year-old girl had been replaced by the eye of arabbit by a Dr. Chibret.[5][6] The operation failed after 15 days due to a lack of effectiveimmunosuppression.[6]
In 1969, Conrad Moore of theTexas Medical Center claimed that he had carried out the transplantation of a whole eye, but he subsequentlyretracted his claim.[7]
In November 2023, surgeons atNYU Langone Health announced the first successful eye transplantation,[8] which was carried out as part of a partialface transplant in an operation that took 21 hours.[8] The recipient, Aaron James, had lost the left side of his face with his eye, nose and mouth in ahigh-voltage power line accident.[8]Reuters reported that the transplanted eye has "well-functioning blood vessels and a promising-looking retina".[8] The eye is not using the optic nerve to communicate with the brain, and James has not regained sight through the eye.[8]Adult stem cells have been harvested from his bone marrow and been injected into the optic nerve.[8] The lead surgeon, Eduardo D. Rodriguez, said that "If some form of vision restoration occurred, it would be wonderful, but ... the goal was for us to perform the technical operation".[8]