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Extended-spectrum penicillin

From Wikipedia, the free encyclopedia
Group of antibiotics that have the widest antibacterial spectrum of all penicillins

Theextended-spectrum penicillins are a group ofantibiotics that have the widest antibacterial spectrum of allpenicillins.[1] Some sources identify them withantipseudomonal penicillins,[2] others consider these types to be distinct.[3] This group includes thecarboxypenicillins and theureidopenicillins.Aminopenicillins, in contrast, do not have activity againstPseudomonas species, as their positively charged amino group does not hinder degradation by bacterially producedbeta-lactamases.[4]

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References

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  1. ^Comprehensive Pharmacy Review, Leon Shargel, 6th edition, p917
  2. ^Kester, Mark; Karpa, Kelly Dowhower;Vrana, Kent E. (2011).Elsevier's Integrated Review Pharmacology E-Book. Elsevier Health Sciences.ISBN 9781455727032.
  3. ^Clark, Michelle A.; Harvey, Richard A.; Finkel, Richard; Rey, Jose A.; Whalen, Karen, eds. (2011).Pharmacology. Lippincott Williams & Wilkins. p. 383.ISBN 9781451113143.
  4. ^Golan, David E. (15 December 2011).Principles of Pharmacology (2 ed.). Lippincott Williams & Wilkins. p. 610.ISBN 978-1608312702.
β-lactams
(inhibit synthesis
of peptidoglycan
layer of bacterial
cell wall by binding
to and inhibiting
PBPs, a group of
D-alanyl-D-alanine
transpeptidases
)
Penicillins (Penams)
Narrow
spectrum
β-lactamase sensitive
(1st generation)
β-lactamase resistant
(2nd generation)
Extended
spectrum
Aminopenicillins (3rd generation)
Carboxypenicillins (4th generation)
Ureidopenicillins (4th generation)
Other
Carbapenems /Penems
Cephems
Cephalosporins
Cephamycins
Carbacephems
1st generation
2nd generation
3rd generation
4th generation
5th generation
Siderophore
Veterinary
Monobactams
β-lactamase inhibitors
Combinations
Polypeptides
Lipopeptides
Other
  • Inhibits PG elongation and crosslinking:Ramoplanin§
Intracellular
Other
Retrieved from "https://en.wikipedia.org/w/index.php?title=Extended-spectrum_penicillin&oldid=1141568243"
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