Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Evocalcet

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Evocalcet
Clinical data
Trade namesOrkedia
ATC code
Identifiers
  • 2-[4-[(3S)-3-[[(1R)-1-Naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]acetic acid
CAS Number
PubChemCID
DrugBank
UNII
KEGG
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC24H26N2O2
Molar mass374.484 g·mol−1

Evocalcet (trade nameOrkedia) is a drug for the treatment ofhyperparathyroidism.[1] It acts as acalcium-sensing receptoragonist.[2]

In 2018, it was approved in Japan for treatment of secondary hyperparathyroidism in patients ondialysis.[3]

References

[edit]
  1. ^Kawata T, Tokunaga S, Murai M, Masuda N, Haruyama W, Shoukei Y, et al. (2018)."A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro".PLOS ONE.13 (4) e0195316.Bibcode:2018PLoSO..1395316K.doi:10.1371/journal.pone.0195316.PMC 5882164.PMID 29614098.
  2. ^Miyazaki H, Ikeda Y, Sakurai O, Miyake T, Tsubota R, Okabe J, et al. (June 2018)."Discovery of evocalcet, a next-generation calcium-sensing receptor agonist for the treatment of hyperparathyroidism".Bioorganic & Medicinal Chemistry Letters.28 (11):2055–2060.doi:10.1016/j.bmcl.2018.04.055.PMID 29724589.
  3. ^"Kyowa Hakko Kirin Launches Orkedia Tablets (Evocalcet) for the Treatment of Secondary Hyperparathyroidism in Patients on Maintenance Dialysis in Japan" (Press release). Kyowa Hakko Kirin. May 22, 2018.
Parathyroid hormone and analogues
Anti-parathyroid hormone agents
Calcitonin derivatives
Calcimimetics
Other


Stub icon

Thishormonal preparation article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Evocalcet&oldid=1313898080"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp