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Eticyclidine

From Wikipedia, the free encyclopedia
Medication

Pharmaceutical compound
Eticyclidine
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • N-Ethyl-1-phenylcyclohexylamine
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC14H21N
Molar mass203.329 g·mol−1
3D model (JSmol)
  • CCNC1(CCCCC1)C2=CC=CC=C2
  • InChI=1S/C14H21N/c1-2-15-14(11-7-4-8-12-14)13-9-5-3-6-10-13/h3,5-6,9-10,15H,2,4,7-8,11-12H2,1H3 checkY
  • Key:IFYLVUHLOOCYBG-UHFFFAOYSA-N checkY
  (verify)

PCE (Eticyclidine,CI-400) is adissociativeanesthetic drug withhallucinogenic effects. It is similar in effects tophencyclidine but is slightly more potent. PCE was developed byParke-Davis in the 1970s and evaluated for anesthetic potential under the code name CI-400,[2] but research into PCE was not continued after the development ofketamine, a similar drug with more favourable properties.[3] Due to its similarity in effects to PCP, PCE was placed into the Schedule 1 list of illegal drugs in the 1970s, although it was only briefly abused in the 1970s and 1980s and is now little known.[4]

See also

[edit]

References

[edit]
  1. ^Anvisa (2023-07-24)."RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-07-25).Archived from the original on 2023-08-27. Retrieved2023-08-27.
  2. ^Levy L, Cameron DE, Aitken RC (March 1960). "Observation on two psychotomimetic drugs of piperidine derivation--CI 395 (sernyl) and CI 400".The American Journal of Psychiatry.116 (9):843–844.doi:10.1176/ajp.116.9.843.PMID 14416411.
  3. ^Kalir A, Edery H, Pelah Z, Balderman D, Porath G (May 1969). "1-Phenycycloalkylamine derivatives. II. Synthesis and pharmacological activity".Journal of Medicinal Chemistry.12 (3):473–477.doi:10.1021/jm00303a030.PMID 4977945.
  4. ^Morris H, Wallach J (July 2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs".Drug Testing and Analysis.6 (7–8):614–632.doi:10.1002/dta.1620.PMID 24678061.
Inhalational
Injection
Phenols
Barbiturates
Benzodiazepines
Opioids
Arylcyclohexylamines
Neuroactive steroids
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Arylcyclo‐
hexylamines
Adamantanes
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D1-like
Agonists
PAMs
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Agonists
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AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
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