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Eticlopride

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Chemical compound

Pharmaceutical compound

Eticlopride
Clinical data

ATC code	none
Identifiers
IUPAC name 5-chloro-3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
CAS Number	84226-12-0^Y HCl: 97612-24-3^Y
PubChemCID	57267
IUPHAR/BPS	966
ChemSpider	51626^N
UNII	J8M468HBH4 HCl: HJ2CAH4TZ1^Y
ChEMBL	ChEMBL8946^N
CompTox Dashboard(EPA)	DTXSID9048435
Chemical and physical data
Formula	C₁₇H₂₅ClN₂O₃
Molar mass	340.85 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl
^NY (what is this?) (verify)

Eticlopride is a selectivedopamine antagonist that acts onD₂ dopamine receptor. It is primarily used in pharmacological research.^[1]^[2]^[3]^[4]

^"Eticlopride hydrochloride".Abcam.
^Claytor R, Lile JA, Nader MA (March 2006). "The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys".Pharmacology, Biochemistry, and Behavior.83 (3):456–64.doi:10.1016/j.pbb.2006.03.007.PMID 16631246.S2CID 39482275.
^Hemby SE, Smith JE, Dworkin SI (June 1996). "The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats".The Journal of Pharmacology and Experimental Therapeutics.277 (3):1247–58.doi:10.1016/S0022-3565(25)13070-X.PMID 8667185.
^Haile CN, Kosten TA (November 2001). "Differential effects of D1- and D2-like compounds on cocaine self-administration in Lewis and Fischer 344 inbred rats".The Journal of Pharmacology and Experimental Therapeutics.299 (2):509–18.doi:10.1016/S0022-3565(24)29257-0.PMID 11602661.

Eticlopride at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Agonists	Benzazepines:6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam Zelandopam Ergolines:Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride Dihydrexidine derivatives:A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines:BCO-001 Deoxyepinephrine (N-methyldopamine, epinine) Dipropyldopamine (DPDA) Dopamine Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Lu AE04621 Melevodopa L-Phenylalanine L-Tyrosine XP21279 Others:A-68930 Apomorphine Isocorypalmine Lu AF28996 Nuciferine PF-06412562 PF-6649751 PF 6669571 Propylnorapomorphine Rotigotine SKF-89,145 SKF-89,626 Stepholidine Tavapadon Tetrahydropalmatine
PAMs	Tetrahydroisoquinolines:DETQ DPTQ Glovadalen Mevidalen
Antagonists	Typical antipsychotics:Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol Atypical antipsychotics:Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine Others:Berupipam Ecopipam EEDQ Metitepine (methiothepin) Odapipam Perlapine SCH-23390

Agonists

Antagonists

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