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Ethadione

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Chemical compound

Not to be confused withethanedione orethenedione.

Pharmaceutical compound

Ethadione
Clinical data

ATC code	N03AC03 (WHO)
Identifiers
IUPAC name 3-Ethyl-5,5-dimethyl-1,3-oxazolidine-2,4-dione
CAS Number	520-77-4^Y
PubChemCID	10630
ChemSpider	10184^Y
UNII	I0F8O700BB
KEGG	C17724^Y
ChEMBL	ChEMBL93047^Y
CompTox Dashboard(EPA)	DTXSID90199972
ECHA InfoCard	100.007.544
Chemical and physical data
Formula	C₇H₁₁NO₃
Molar mass	157.169 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C1N(C(=O)OC1(C)C)CC
InChI InChI=1S/C7H11NO3/c1-4-8-5(9)7(2,3)11-6(8)10/h4H2,1-3H3^Y Key:SIGSNYAYBSJATD-UHFFFAOYSA-N^Y
(verify)

Ethadione is ananticonvulsant medication in theoxazolidinedione family used mainly to treatseizures.^[1]

^Bergstrand A, Bergstrand CG, Engstrom N, Herrlin KM (October 1962). "Renal histology during treatment with oxazolidine-diones (trimethadione, ethadione, and paramethadione)".Pediatrics.30 (4):601–7.doi:10.1542/peds.30.4.601.PMID 13970793.S2CID 7313535.

GABA_AR PAMs	Barbiturates:Barbexaclone Metharbital Methylphenobarbital Pentobarbital Phenobarbital^# Primidone;Carbamates:Cenobamate Felbamate;Benzodiazepines:Clobazam Clonazepam Clorazepate Diazepam^# Lorazepam^# Midazolam Nimetazepam Nitrazepam Temazepam;Others:Bromide (potassium bromide,sodium bromide) Imepitoin Paraldehyde Stiripentol
GABA-T inhibitors	Fatty acids (and related):Valproate Valpromide Valproate pivoxil Vigabatrin
Others	GABAR agonists:Progabide;GAT-1 inhibitors:Tiagabine

Sodium blockers	Hydantoins:Ethotoin Fosphenytoin Mephenytoin Phenytoin^#;Ureides:Acetylpheneturide Chlorphenacemide Phenacemide^‡ Pheneturide;Fatty acids:Valproate Valpromide Valproate pivoxil;Carboxamides: Carbamazepine^# Eslicarbazepine acetate Oxcarbazepine;Others:Lacosamide Lamotrigine^# Rufinamide Topiramate Zonisamide
Calcium blockers	Oxazolidinediones:Ethadione Paramethadione Trimethadione;Succinimides:Ethosuximide^# Mesuximide Phensuximide;Gabapentinoids:Gabapentin Pregabalin;Others:Imepitoin Lamotrigine^# Topiramate Zonisamide
Potassium openers	Retigabine

Others

CA inhibitors	Sulfonamides:Acetazolamide Ethoxzolamide Sultiame Topiramate Zonisamide
Others	Albutoin Beclamide Brivaracetam Cannabidiol Carisbamate Etiracetam Fenfluramine Ganaxolone Levetiracetam Perampanel

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