-Epoxiconazole_Structural_Formulea_V.1.svg) | |
| Names | |
|---|---|
| IUPAC name (2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4-triazole | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI |
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| ChemSpider |
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| ECHA InfoCard | 100.100.840 |
| KEGG | |
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| Properties | |
| C17H13ClFN3O | |
| Molar mass | 329.76 g mol |
| Density | 1.374 g/cm3 |
| Melting point | 134 °C (273 °F; 407 K) |
| 8.42 ppm, at 20°C in water | |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Epoxiconazole is afungicide active ingredient from the class ofazoles developed to protect crops. In particular, the substance inhibits the metabolism of fungi cells infesting useful plants, and thereby prevents the growth of themycelia (fungal cells). Epoxiconazole also limits the production ofconidia (mitospores). Epoxiconazole was introduced to the market byBASF SE in 1993 and can be found in many products and product mixtures targeting a large number of pathogens in various crops. Crops are, for example, cereals (mainly wheat, barley, rye and triticale), soybeans, banana, rice, coffee, turnips, and red as well as sugar beets.
Epoxiconazole is used against, amongst others, cereal diseases, two of which, namely leaf blotch (Septoria tritici) and rust (Puccinia triticina), are responsible for up to 30% yield losses.[2] Although not used commercially for insect control, epoxiconazole exhibits a strong anti-feeding effect on the keratin-digesting common clothes moth larvaeTineola bisselliella.[3]
Certain plant pathogens developresistance to fungicides. In contrast to the relatively rapid development of resistance tostrobilurins, azole fungicides like Epoxiconazole have maintained their effectiveness controlling key wheat diseases for over two decades.[4] According to a study conducted by theHome Grown Cereals Authority (HGCA), Epoxiconazole was one of two triazole fungicides (the other being prothioconazole) reported to still provide a high level of eradicative and protective control ofSeptoria tritici.[5] Additional classes of fungicides like contact fungicides, strobilurins or carboxamides are available to farmers. In the latter case, the best activity rates are achieved in mixtures with triazoles.[6]
As an azole, Epoxiconazole, actively stops the production of new fungi spores and inhibits the biosynthesis of existing hostile cells. Epoxiconazole works as an eradicant by encapsulating fungalhaustoria, which are then cut off from their nutrient supply and therefore die. Some fungicide interactions can actually lead to increased production ofmycotoxins, which are normal metabolic products of fungi, and it has been found that the inclusion of triazoles, like Epoxiconazole, in the fungicide mix may be necessary to limit mycotoxin levels.[7]
InEurope, the active substance epoxiconazole has been withdrawn by industry from the approval process underRegulation (EC) No 1107/2009. The effect of that withdrawal is that epoxiconazole is banned from all use in the category ‘pesticides’, due to the fact that it has not been approved for any other use in that category.
In addition, the harmonised classification of epoxiconazole under Regulation (EC) No 1272/2008 of the European Parliament and of the Council[8] is sufficient evidence that the substance raises concerns for human health and the environment.
According to theEuropean Chemicals Agency, Epoxiconazole is verytoxic to aquatic life with long lasting effects, maydamage fertility or theunborn child, and is suspected ofcausing cancer.[9]
