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Epoetin theta

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From Wikipedia, the free encyclopedia

Pharmaceutical compound

Epoetin theta
Clinical data
Trade names	Biopoin, Eporatio
ATC code	None
Legal status
Legal status	EU: Rx-only [1]^[2]
Identifiers
CAS Number	762263-14-9
PubChem SID	135315770
DrugBank	DB00016
Chemical and physical data
Formula	C₈₁₅H₁₃₁₇N₂₃₃O₂₄₁S₅
Molar mass	18396.19 g·mol⁻¹

Epoetin theta, sold under the brand nameBiopoin among others, is a form of the human hormoneerythropoietin produced using recombinant DNA technology.^[1]^[2]

It acts as a short actingerythropoiesis-stimulating agent (ESA) for the treatment ofanemia associated withchronic kidney disease andchemotherapy-induced anemia in patients with cancer.^[3]

Medical uses

[edit]

Epoetin theta isindicated for the treatment of symptomaticanemia in adults.^[1]

Side effects

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The most common side effects include shunt thrombosis (clots that can form in blood vessels of patients on dialysis, a blood clearance technique),headache,hypertension (high blood pressure),hypertensive crisis (sudden, dangerously high blood pressure),skin reactions,arthralgia (joint pain) andinfluenza (flu)-like illness.^[1] Epoetin theta was authorized for medical use in the European Union in October 2009.^[1] It is on theWorld Health Organization's List of Essential Medicines.^[4]

References

[edit]

^^a ^b ^c ^d ^e"Biopoin EPAR".European Medicines Agency (EMA). 16 December 2009. Retrieved26 January 2021. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
^^a ^b"Eporatio EPAR".European Medicines Agency (EMA). 16 December 2009. Retrieved26 January 2021. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
^Forbes CA, Worthy G, Harker J, Kleijnen J, Kutikova L, Zelek L, Van Belle S (April 2014). "Dose efficiency of erythropoiesis-stimulating agents for the treatment of patients with chemotherapy-induced anemia: a systematic review".Clinical Therapeutics.36 (4):594–610.doi:10.1016/j.clinthera.2014.02.007.PMID 24656152.
^World Health Organization (2021).World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization.hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

attribution contains material copied from Biopoin | European Medicines Agencyhttps://www.ema.europa.eu/en/medicines/human/EPAR/biopoin 2021

External links

[edit]

"Epoetin theta".Drug Information Portal. U.S. National Library of Medicine. Archived fromthe original on 1 February 2021.

v t e Antianemic preparations (B03)
Erythropoietins	Erythropoietin Darbepoetin alfa Methoxy polyethylene glycol-epoetin beta Peginesatide
Iron supplements	Ferric hydroxide Ferric maltol Ferrous ascorbate Ferrous aspartate Ferrous carbonate Ferrous chloride Ferric derisomaltose Ferrous fumarate Ferrous gluconate Ferrous glycine sulfate Ferrous iodine Ferrous succinate Ferrous sulfate Ferrous tartrate Iron sucrose Sodium ferric gluconate complex
Vitamin B12 and folic acid supplements	Cyanocobalamin Cyanocobalamin tannin complex Hydroxocobalamin Cobamamide Mecobalamin Folic acid
HIF prolyl-hydroxylase inhibitors	Daprodustat Desidustat Enarodustat Molidustat Roxadustat Vadadustat
Other	Luspatercept

Cytokine receptor modulators

Chemokine

Seehere instead.

CSF

Erythropoietin	Agonists:ARA-290 Asialo erythropoietin Carbamylated erythropoietin CNTO-530 Darbepoetin alfa Epoetin alfa Epoetin beta Epoetin delta Epoetin epsilon Epoetin gamma Epoetin kappa Epoetin omega Epoetin theta Epoetin zeta Erythropoietin (EPO) Erythropoietin-Fc Methoxy polyethylene glycol-epoetin beta (CERA/Mircera) Peginesatide Pegol sihematide (EPO-018B)
G-CSF (CSF3)	Agonists:Filgrastim Granulocyte colony-stimulating factor Lenograstim Leridistim Lipegfilgrastim Nartograstim Pegfilgrastim Pegnartograstim
GM-CSF (CSF2)	Agonists:Ecogramostim Granulocyte macrophage colony-stimulating factor Milodistim Molgramostim Regramostim Sargramostim Antibodies:Mavrilimumab Namilumab Otilimab
M-CSF (CSF1)	Agonists:Cilmostim Interleukin-34 Lanimostim Macrophage colony-stimulating factor Mirimostim Kinase inhibitors:Agerafenib
SCF (c-Kit)	Seehere instead.
Thrombopoietin	Agonists:Eltrombopag Pegacaristim Promegapoietin Romiplostim Thrombopoietin (THPO, MGDF)

Interferon

IFNAR (α/β, I)	Agonists:Albinterferon Interferon alpha (interferon alfa, IFN-α) Interferon alfa (IFNA1,IFNA2,IFNA4,IFNA5,IFNA6,IFNA7,IFNA8,IFNA10,IFNA13,IFNA14,IFNA16,IFNA17,IFNA21) Interferon alfa 2a Interferon alfa 2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 Interferon beta (IFN-β) (IFNB1,IFNB3) Interferon beta 1a Interferon beta 1b Interferon kappa (IFN-ε/κ/τ/ζ, IFNK) Interferon omega (IFN-ω, IFNW1) Peginterferon alfa-2a Peginterferon alfa-2b Antibodies:Anifrolumab Faralimomab MEDI-545 Rontalizumab Sifalimumab Decoy receptors:Bifarcept
IFNGR (γ, II)	Agonists:Interferon gamma (IFN-γ) Interferon gamma 1b Antibodies:Emapalumab Fontolizumab
IFNLR (λ, III)	See IL-28R (IFNLR)here instead.

Interleukin

Seehere instead.

TGFβ

Seehere instead.

TNF

Seehere instead.

Others

JAK
(inhibitors)

JAK1	Abrocitinib Baricitinib Deuruxolitinib Filgotinib Momelotinib Oclacitinib Peficitinib Ruxolitinib Tofacitinib (tasocitinib) Upadacitinib
JAK2	Atiprimod AZD-1480 Baricitinib CHZ868 Cucurbitacin I (elatericin B, JSI-124) CYT387 Deuruxolitinib Lestaurtinib NSC-7908 NSC-33994 Pacritinib Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib)
JAK3	Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P 154 ZM-39923 ZM-449829
TYK2	Deucravacitinib

Others

Additional cytokine receptor modulators:Emfilermin
Lestaurtinib
Midostaurin
Quizartinib
Sorafenib
Sunitinib

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