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| Names | |
|---|---|
| IUPAC name (RS)-N-[2-([3-(2-cyanophenoxy)-2-hydroxypropyl]amino)ethyl]-2-(4-hydroxyphenyl)acetamide | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider |
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| KEGG |
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| UNII | |
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| Properties | |
| C20H23N3O4 | |
| Molar mass | 369.41432 |
| Pharmacology | |
| C07AB10 (WHO) | |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Epanolol is abeta blocker.[1] developed byImperial Chemical Industries.[2]
Theester methyl 4-benzyloxyphenylacetate (1) is treated withethylenediamine to give theamide (3). Separately, 2-cyanophenol (4) is reacted withepichlorohydrin andsodium hydroxide to produce thebenzonitrile derivative (5). Combination of (3) and (5) by heating inpropanol gives (6). Lastly, catalytic hydrogenation removes the benzylprotecting group and yields epanolol.[2][3]
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