 | |
| Names | |
|---|---|
| IUPAC name (5Z,8Z,10E,12E,14R,15S)-14-{[(2R)-2-Amino-2-carboxyethyl]sulfanyl}-15-hydroxy-5,8,10,12-icosatetraenoic acid | |
| Other names EXE4; 14,15-LTE4; 14,15-Leukotriene E4 | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChemSpider | |
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| Properties | |
| C23H37NO5S | |
| Molar mass | 439.61 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Eoxin E4 (EXE4), also known as14,15-leukotriene E4, is aneoxin. Cells make eoxins by metabolizingarachidonic acid with a15-lipoxygenase enzyme to form(15S)-hydroperoxyeicosapentaenoic acid (i.e. 15(S)-HpETE). This product is then converted serially toEXA4,EXC4,EXD4, and EXE4 byLTC4 synthase, an unidentifiedgamma-glutamyltransferase, and an unidentifieddipeptidase, respectively, in a pathway which appears similar if not identical to the pathway which formsleukotrienes, i.e.LTA4,LTC4,LTD4, andLTE4. This pathway is schematically shown as follows:[1][2]
EXA4 is viewed as an intracellular-bound, short-lived intermediate which is rapidly metabolized to the downstream eoxins. The eoxins downstream of EXA4 are secreted from their parent cells and, it is proposed but not yet proven, serve to regulate allergic responses and the development of certain cancers (seeeoxins).[1][3]
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